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Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization

Stripping crystallization (SC) is introduced in this work for chiral purification of R-phenylglycinol from the enantiomer mixture with an initial concentration ranging from 0.90 to 0.97. As opposed to the solid–liquid transformation in melt crystallization, the three-phase transformation occurs in S...

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Autor principal: Shiau, Lie-Ding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278477/
https://www.ncbi.nlm.nih.gov/pubmed/30405042
http://dx.doi.org/10.3390/molecules23112901
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author Shiau, Lie-Ding
author_facet Shiau, Lie-Ding
author_sort Shiau, Lie-Ding
collection PubMed
description Stripping crystallization (SC) is introduced in this work for chiral purification of R-phenylglycinol from the enantiomer mixture with an initial concentration ranging from 0.90 to 0.97. As opposed to the solid–liquid transformation in melt crystallization, the three-phase transformation occurs in SC at low pressures during the cooling process. SC combines melt crystallization and vaporization to produce a crystalline product and mixture vapor from a mixture melt due to the three-phase transformation. Thermodynamic calculations were applied to determine the operating pressure for the three-phase transformation during the cooling process in the SC experiments. To consider the possible deviations between the calculated and the actual three-phase transformation conditions, the product purity and the recovery ratio of R-phenylglycinol were investigated within a range of operating pressures during the cooling process.
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spelling pubmed-62784772018-12-13 Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization Shiau, Lie-Ding Molecules Article Stripping crystallization (SC) is introduced in this work for chiral purification of R-phenylglycinol from the enantiomer mixture with an initial concentration ranging from 0.90 to 0.97. As opposed to the solid–liquid transformation in melt crystallization, the three-phase transformation occurs in SC at low pressures during the cooling process. SC combines melt crystallization and vaporization to produce a crystalline product and mixture vapor from a mixture melt due to the three-phase transformation. Thermodynamic calculations were applied to determine the operating pressure for the three-phase transformation during the cooling process in the SC experiments. To consider the possible deviations between the calculated and the actual three-phase transformation conditions, the product purity and the recovery ratio of R-phenylglycinol were investigated within a range of operating pressures during the cooling process. MDPI 2018-11-07 /pmc/articles/PMC6278477/ /pubmed/30405042 http://dx.doi.org/10.3390/molecules23112901 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shiau, Lie-Ding
Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization
title Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization
title_full Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization
title_fullStr Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization
title_full_unstemmed Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization
title_short Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization
title_sort chiral separation of the phenylglycinol enantiomers by stripping crystallization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278477/
https://www.ncbi.nlm.nih.gov/pubmed/30405042
http://dx.doi.org/10.3390/molecules23112901
work_keys_str_mv AT shiaulieding chiralseparationofthephenylglycinolenantiomersbystrippingcrystallization