Cargando…
Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization
Stripping crystallization (SC) is introduced in this work for chiral purification of R-phenylglycinol from the enantiomer mixture with an initial concentration ranging from 0.90 to 0.97. As opposed to the solid–liquid transformation in melt crystallization, the three-phase transformation occurs in S...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278477/ https://www.ncbi.nlm.nih.gov/pubmed/30405042 http://dx.doi.org/10.3390/molecules23112901 |
_version_ | 1783378375262339072 |
---|---|
author | Shiau, Lie-Ding |
author_facet | Shiau, Lie-Ding |
author_sort | Shiau, Lie-Ding |
collection | PubMed |
description | Stripping crystallization (SC) is introduced in this work for chiral purification of R-phenylglycinol from the enantiomer mixture with an initial concentration ranging from 0.90 to 0.97. As opposed to the solid–liquid transformation in melt crystallization, the three-phase transformation occurs in SC at low pressures during the cooling process. SC combines melt crystallization and vaporization to produce a crystalline product and mixture vapor from a mixture melt due to the three-phase transformation. Thermodynamic calculations were applied to determine the operating pressure for the three-phase transformation during the cooling process in the SC experiments. To consider the possible deviations between the calculated and the actual three-phase transformation conditions, the product purity and the recovery ratio of R-phenylglycinol were investigated within a range of operating pressures during the cooling process. |
format | Online Article Text |
id | pubmed-6278477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62784772018-12-13 Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization Shiau, Lie-Ding Molecules Article Stripping crystallization (SC) is introduced in this work for chiral purification of R-phenylglycinol from the enantiomer mixture with an initial concentration ranging from 0.90 to 0.97. As opposed to the solid–liquid transformation in melt crystallization, the three-phase transformation occurs in SC at low pressures during the cooling process. SC combines melt crystallization and vaporization to produce a crystalline product and mixture vapor from a mixture melt due to the three-phase transformation. Thermodynamic calculations were applied to determine the operating pressure for the three-phase transformation during the cooling process in the SC experiments. To consider the possible deviations between the calculated and the actual three-phase transformation conditions, the product purity and the recovery ratio of R-phenylglycinol were investigated within a range of operating pressures during the cooling process. MDPI 2018-11-07 /pmc/articles/PMC6278477/ /pubmed/30405042 http://dx.doi.org/10.3390/molecules23112901 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shiau, Lie-Ding Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization |
title | Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization |
title_full | Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization |
title_fullStr | Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization |
title_full_unstemmed | Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization |
title_short | Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization |
title_sort | chiral separation of the phenylglycinol enantiomers by stripping crystallization |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278477/ https://www.ncbi.nlm.nih.gov/pubmed/30405042 http://dx.doi.org/10.3390/molecules23112901 |
work_keys_str_mv | AT shiaulieding chiralseparationofthephenylglycinolenantiomersbystrippingcrystallization |