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Concise Synthesis of (+)-β- and γ-Apopicropodophyllins, and Dehydrodesoxypodophyllotoxin
Herein, we present an expeditous synthesis of bioactive aryldihydronaphthalene lignans (+)-β- and γ-apopicropodophyllins, and arylnaphthalene lignan dehydrodesoxypodophyllotoxin. The key reaction is regiocontrolled oxidations of stereodivergent aryltetralin lactones, which were easily accessed from...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278515/ https://www.ncbi.nlm.nih.gov/pubmed/30469319 http://dx.doi.org/10.3390/molecules23113037 |
| _version_ | 1783378384154263552 |
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| author | Xiao, Jian Nan, Guangming Wang, Ya-Wen Peng, Yu |
| author_facet | Xiao, Jian Nan, Guangming Wang, Ya-Wen Peng, Yu |
| author_sort | Xiao, Jian |
| collection | PubMed |
| description | Herein, we present an expeditous synthesis of bioactive aryldihydronaphthalene lignans (+)-β- and γ-apopicropodophyllins, and arylnaphthalene lignan dehydrodesoxypodophyllotoxin. The key reaction is regiocontrolled oxidations of stereodivergent aryltetralin lactones, which were easily accessed from a nickel-catalyzed reductive cascade approach developed in our group. |
| format | Online Article Text |
| id | pubmed-6278515 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62785152018-12-13 Concise Synthesis of (+)-β- and γ-Apopicropodophyllins, and Dehydrodesoxypodophyllotoxin Xiao, Jian Nan, Guangming Wang, Ya-Wen Peng, Yu Molecules Communication Herein, we present an expeditous synthesis of bioactive aryldihydronaphthalene lignans (+)-β- and γ-apopicropodophyllins, and arylnaphthalene lignan dehydrodesoxypodophyllotoxin. The key reaction is regiocontrolled oxidations of stereodivergent aryltetralin lactones, which were easily accessed from a nickel-catalyzed reductive cascade approach developed in our group. MDPI 2018-11-21 /pmc/articles/PMC6278515/ /pubmed/30469319 http://dx.doi.org/10.3390/molecules23113037 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Communication Xiao, Jian Nan, Guangming Wang, Ya-Wen Peng, Yu Concise Synthesis of (+)-β- and γ-Apopicropodophyllins, and Dehydrodesoxypodophyllotoxin |
| title | Concise Synthesis of (+)-β- and γ-Apopicropodophyllins, and Dehydrodesoxypodophyllotoxin |
| title_full | Concise Synthesis of (+)-β- and γ-Apopicropodophyllins, and Dehydrodesoxypodophyllotoxin |
| title_fullStr | Concise Synthesis of (+)-β- and γ-Apopicropodophyllins, and Dehydrodesoxypodophyllotoxin |
| title_full_unstemmed | Concise Synthesis of (+)-β- and γ-Apopicropodophyllins, and Dehydrodesoxypodophyllotoxin |
| title_short | Concise Synthesis of (+)-β- and γ-Apopicropodophyllins, and Dehydrodesoxypodophyllotoxin |
| title_sort | concise synthesis of (+)-β- and γ-apopicropodophyllins, and dehydrodesoxypodophyllotoxin |
| topic | Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278515/ https://www.ncbi.nlm.nih.gov/pubmed/30469319 http://dx.doi.org/10.3390/molecules23113037 |
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