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Olfactory, Taste, and Photo Sensory Receptors in Non-sensory Organs: It Just Makes Sense

Sensory receptors that detect and respond to light, taste, and smell primarily belong to the G-protein-coupled receptor (GPCR) superfamily. In addition to their established roles in the nose, tongue, and eyes, these sensory GPCRs have been found in many ‘non-sensory' organs where they respond t...

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Autores principales: Dalesio, Nicholas M., Barreto Ortiz, Sebastian F., Pluznick, Jennifer L., Berkowitz, Dan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278613/
https://www.ncbi.nlm.nih.gov/pubmed/30542293
http://dx.doi.org/10.3389/fphys.2018.01673
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author Dalesio, Nicholas M.
Barreto Ortiz, Sebastian F.
Pluznick, Jennifer L.
Berkowitz, Dan E.
author_facet Dalesio, Nicholas M.
Barreto Ortiz, Sebastian F.
Pluznick, Jennifer L.
Berkowitz, Dan E.
author_sort Dalesio, Nicholas M.
collection PubMed
description Sensory receptors that detect and respond to light, taste, and smell primarily belong to the G-protein-coupled receptor (GPCR) superfamily. In addition to their established roles in the nose, tongue, and eyes, these sensory GPCRs have been found in many ‘non-sensory' organs where they respond to different physicochemical stimuli, initiating signaling cascades in these extrasensory systems. For example, taste receptors in the airway, and photoreceptors in vascular smooth muscle cells, both cause smooth muscle relaxation when activated. In addition, olfactory receptors are present within the vascular system, where they play roles in angiogenesis as well as in modulating vascular tone. By better understanding the physiological and pathophysiological roles of sensory receptors in non-sensory organs, novel therapeutic agents can be developed targeting these receptors, ultimately leading to treatments for pathological conditions and potential cures for various disease states.
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spelling pubmed-62786132018-12-12 Olfactory, Taste, and Photo Sensory Receptors in Non-sensory Organs: It Just Makes Sense Dalesio, Nicholas M. Barreto Ortiz, Sebastian F. Pluznick, Jennifer L. Berkowitz, Dan E. Front Physiol Physiology Sensory receptors that detect and respond to light, taste, and smell primarily belong to the G-protein-coupled receptor (GPCR) superfamily. In addition to their established roles in the nose, tongue, and eyes, these sensory GPCRs have been found in many ‘non-sensory' organs where they respond to different physicochemical stimuli, initiating signaling cascades in these extrasensory systems. For example, taste receptors in the airway, and photoreceptors in vascular smooth muscle cells, both cause smooth muscle relaxation when activated. In addition, olfactory receptors are present within the vascular system, where they play roles in angiogenesis as well as in modulating vascular tone. By better understanding the physiological and pathophysiological roles of sensory receptors in non-sensory organs, novel therapeutic agents can be developed targeting these receptors, ultimately leading to treatments for pathological conditions and potential cures for various disease states. Frontiers Media S.A. 2018-11-27 /pmc/articles/PMC6278613/ /pubmed/30542293 http://dx.doi.org/10.3389/fphys.2018.01673 Text en Copyright © 2018 Dalesio, Barreto Ortiz, Pluznick and Berkowitz. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Dalesio, Nicholas M.
Barreto Ortiz, Sebastian F.
Pluznick, Jennifer L.
Berkowitz, Dan E.
Olfactory, Taste, and Photo Sensory Receptors in Non-sensory Organs: It Just Makes Sense
title Olfactory, Taste, and Photo Sensory Receptors in Non-sensory Organs: It Just Makes Sense
title_full Olfactory, Taste, and Photo Sensory Receptors in Non-sensory Organs: It Just Makes Sense
title_fullStr Olfactory, Taste, and Photo Sensory Receptors in Non-sensory Organs: It Just Makes Sense
title_full_unstemmed Olfactory, Taste, and Photo Sensory Receptors in Non-sensory Organs: It Just Makes Sense
title_short Olfactory, Taste, and Photo Sensory Receptors in Non-sensory Organs: It Just Makes Sense
title_sort olfactory, taste, and photo sensory receptors in non-sensory organs: it just makes sense
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278613/
https://www.ncbi.nlm.nih.gov/pubmed/30542293
http://dx.doi.org/10.3389/fphys.2018.01673
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