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Organophosphine-Catalyzed [4C+X] Annulations
In recent years, there have been extraordinary developments of organophosphine-catalyzed reactions. This includes progress in the area of [4C+X] annulations, which are of particular interest due to their potential for the rapid construction of 5–8-membered cyclic products. In this short overview, we...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278662/ https://www.ncbi.nlm.nih.gov/pubmed/30463230 http://dx.doi.org/10.3390/molecules23113022 |
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author | Li, Yangyan Chen, Xiang Chen, Xiaoming Shen, Xiao |
author_facet | Li, Yangyan Chen, Xiang Chen, Xiaoming Shen, Xiao |
author_sort | Li, Yangyan |
collection | PubMed |
description | In recent years, there have been extraordinary developments of organophosphine-catalyzed reactions. This includes progress in the area of [4C+X] annulations, which are of particular interest due to their potential for the rapid construction of 5–8-membered cyclic products. In this short overview, we summarize the remarkable progress, emphasizing reaction mechanisms and key intermediates involved in the processes. The discussion is classified according to the type of electrophilic reactants that acted as C(4) synthons in the annulation process, in the order of α-alkyl allenoates, γ-alkyl allenoates, α-methyl allene ketones, β′-OAc allenoate, δ-OAc allenoate, activated dienes and cyclobutenones. |
format | Online Article Text |
id | pubmed-6278662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62786622018-12-13 Organophosphine-Catalyzed [4C+X] Annulations Li, Yangyan Chen, Xiang Chen, Xiaoming Shen, Xiao Molecules Review In recent years, there have been extraordinary developments of organophosphine-catalyzed reactions. This includes progress in the area of [4C+X] annulations, which are of particular interest due to their potential for the rapid construction of 5–8-membered cyclic products. In this short overview, we summarize the remarkable progress, emphasizing reaction mechanisms and key intermediates involved in the processes. The discussion is classified according to the type of electrophilic reactants that acted as C(4) synthons in the annulation process, in the order of α-alkyl allenoates, γ-alkyl allenoates, α-methyl allene ketones, β′-OAc allenoate, δ-OAc allenoate, activated dienes and cyclobutenones. MDPI 2018-11-19 /pmc/articles/PMC6278662/ /pubmed/30463230 http://dx.doi.org/10.3390/molecules23113022 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Yangyan Chen, Xiang Chen, Xiaoming Shen, Xiao Organophosphine-Catalyzed [4C+X] Annulations |
title | Organophosphine-Catalyzed [4C+X] Annulations |
title_full | Organophosphine-Catalyzed [4C+X] Annulations |
title_fullStr | Organophosphine-Catalyzed [4C+X] Annulations |
title_full_unstemmed | Organophosphine-Catalyzed [4C+X] Annulations |
title_short | Organophosphine-Catalyzed [4C+X] Annulations |
title_sort | organophosphine-catalyzed [4c+x] annulations |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278662/ https://www.ncbi.nlm.nih.gov/pubmed/30463230 http://dx.doi.org/10.3390/molecules23113022 |
work_keys_str_mv | AT liyangyan organophosphinecatalyzed4cxannulations AT chenxiang organophosphinecatalyzed4cxannulations AT chenxiaoming organophosphinecatalyzed4cxannulations AT shenxiao organophosphinecatalyzed4cxannulations |