Synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process

The one-pot four-component reaction of 3-(1H-indol-3-yl)-3-oxopropanenitriles, aromatic aldehydes, cycloalkanones and ammonium acetate occurred via a six-step tandem Knoevenagel condensation–nucleophilic addition to carbonyl–Michael addition–N-cyclization–elimination–air oxidation sequence to afford...

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Autores principales: Muthu, Muthumani, Vishnu Priya, Rakkappan, Almansour, Abdulrahman I, Suresh Kumar, Raju, Kumar, Raju Ranjith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278771/
https://www.ncbi.nlm.nih.gov/pubmed/30546474
http://dx.doi.org/10.3762/bjoc.14.269
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author Muthu, Muthumani
Vishnu Priya, Rakkappan
Almansour, Abdulrahman I
Suresh Kumar, Raju
Kumar, Raju Ranjith
author_facet Muthu, Muthumani
Vishnu Priya, Rakkappan
Almansour, Abdulrahman I
Suresh Kumar, Raju
Kumar, Raju Ranjith
author_sort Muthu, Muthumani
collection PubMed
description The one-pot four-component reaction of 3-(1H-indol-3-yl)-3-oxopropanenitriles, aromatic aldehydes, cycloalkanones and ammonium acetate occurred via a six-step tandem Knoevenagel condensation–nucleophilic addition to carbonyl–Michael addition–N-cyclization–elimination–air oxidation sequence to afford structurally intriguing indole–cycloalkyl[b]pyridine-3-carbonitrile hybrid heterocycles in excellent yields.
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spelling pubmed-62787712018-12-13 Synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process Muthu, Muthumani Vishnu Priya, Rakkappan Almansour, Abdulrahman I Suresh Kumar, Raju Kumar, Raju Ranjith Beilstein J Org Chem Full Research Paper The one-pot four-component reaction of 3-(1H-indol-3-yl)-3-oxopropanenitriles, aromatic aldehydes, cycloalkanones and ammonium acetate occurred via a six-step tandem Knoevenagel condensation–nucleophilic addition to carbonyl–Michael addition–N-cyclization–elimination–air oxidation sequence to afford structurally intriguing indole–cycloalkyl[b]pyridine-3-carbonitrile hybrid heterocycles in excellent yields. Beilstein-Institut 2018-11-22 /pmc/articles/PMC6278771/ /pubmed/30546474 http://dx.doi.org/10.3762/bjoc.14.269 Text en Copyright © 2018, Muthu et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Muthu, Muthumani
Vishnu Priya, Rakkappan
Almansour, Abdulrahman I
Suresh Kumar, Raju
Kumar, Raju Ranjith
Synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process
title Synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process
title_full Synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process
title_fullStr Synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process
title_full_unstemmed Synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process
title_short Synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process
title_sort synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278771/
https://www.ncbi.nlm.nih.gov/pubmed/30546474
http://dx.doi.org/10.3762/bjoc.14.269
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