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Functional chlorin gold nanorods enable to treat breast cancer by photothermal/photodynamic therapy
BACKGROUND: The existing chemo/radiotherapy fail to eliminate cancer cells due to the restriction of either drug resistance or radio tolerance. The predicament urges researchers to continuously explore alternative strategy for achieving a potent curative effect. METHODS: Functional chlorin gold nano...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278843/ https://www.ncbi.nlm.nih.gov/pubmed/30555230 http://dx.doi.org/10.2147/IJN.S186974 |
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author | Liu, Lei Xie, Hong-Jun Mu, Li-Min Liu, Rui Su, Zhan-Bo Cui, Yi-Nuo Xie, Ying Lu, Wan-Liang |
author_facet | Liu, Lei Xie, Hong-Jun Mu, Li-Min Liu, Rui Su, Zhan-Bo Cui, Yi-Nuo Xie, Ying Lu, Wan-Liang |
author_sort | Liu, Lei |
collection | PubMed |
description | BACKGROUND: The existing chemo/radiotherapy fail to eliminate cancer cells due to the restriction of either drug resistance or radio tolerance. The predicament urges researchers to continuously explore alternative strategy for achieving a potent curative effect. METHODS: Functional chlorin gold nanorods (Ce6-AuNR@SiO(2)-d-CPP) were fabricated aiming at treating breast cancer by photothermal/photodynamic therapy (PTT/PDT). The nanostructure was developed by synthesizing Au nanorods as the photothermal conversion material, and by coating the pegylated mesoporous SiO(2) as the shell for entrapping photosensitizer Ce6 and for linking the D-type cell penetrating peptide (d-CPP). The function of Ce6-AuNR@SiO(2)-d-CPP was verified on human breast cancer MCF-7 cells and MCF-7 cells xenografts in nude mice. RESULTS: Under combinational treatment of PTT and PDT, Ce6-AuNR@SiO(2)-d-CPP demonstrated a strong cytotoxicity and apoptosis inducing effects in breast cancer cells in vitro, and a robust treatment efficacy in breast cancer-bearing nude mice. The uptake mechanism involved the energy-consuming caveolin-mediated endocytosis, and Ce6-AuNR@SiO(2)-d-CPP in PTT/PDT mode could induce apoptosis by multiple pathways in breast cancer cells. CONCLUSION: Ce6-AuNR@SiO(2)-d-CPP demonstrated a robust efficacy in the treatment of breast cancer by photothermal/photodynamic therapy. Therefore, the present study could offer a new promising strategy to treat the refractory breast cancer. |
format | Online Article Text |
id | pubmed-6278843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-62788432018-12-14 Functional chlorin gold nanorods enable to treat breast cancer by photothermal/photodynamic therapy Liu, Lei Xie, Hong-Jun Mu, Li-Min Liu, Rui Su, Zhan-Bo Cui, Yi-Nuo Xie, Ying Lu, Wan-Liang Int J Nanomedicine Original Research BACKGROUND: The existing chemo/radiotherapy fail to eliminate cancer cells due to the restriction of either drug resistance or radio tolerance. The predicament urges researchers to continuously explore alternative strategy for achieving a potent curative effect. METHODS: Functional chlorin gold nanorods (Ce6-AuNR@SiO(2)-d-CPP) were fabricated aiming at treating breast cancer by photothermal/photodynamic therapy (PTT/PDT). The nanostructure was developed by synthesizing Au nanorods as the photothermal conversion material, and by coating the pegylated mesoporous SiO(2) as the shell for entrapping photosensitizer Ce6 and for linking the D-type cell penetrating peptide (d-CPP). The function of Ce6-AuNR@SiO(2)-d-CPP was verified on human breast cancer MCF-7 cells and MCF-7 cells xenografts in nude mice. RESULTS: Under combinational treatment of PTT and PDT, Ce6-AuNR@SiO(2)-d-CPP demonstrated a strong cytotoxicity and apoptosis inducing effects in breast cancer cells in vitro, and a robust treatment efficacy in breast cancer-bearing nude mice. The uptake mechanism involved the energy-consuming caveolin-mediated endocytosis, and Ce6-AuNR@SiO(2)-d-CPP in PTT/PDT mode could induce apoptosis by multiple pathways in breast cancer cells. CONCLUSION: Ce6-AuNR@SiO(2)-d-CPP demonstrated a robust efficacy in the treatment of breast cancer by photothermal/photodynamic therapy. Therefore, the present study could offer a new promising strategy to treat the refractory breast cancer. Dove Medical Press 2018-11-29 /pmc/articles/PMC6278843/ /pubmed/30555230 http://dx.doi.org/10.2147/IJN.S186974 Text en © 2018 Liu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Liu, Lei Xie, Hong-Jun Mu, Li-Min Liu, Rui Su, Zhan-Bo Cui, Yi-Nuo Xie, Ying Lu, Wan-Liang Functional chlorin gold nanorods enable to treat breast cancer by photothermal/photodynamic therapy |
title | Functional chlorin gold nanorods enable to treat breast cancer by photothermal/photodynamic therapy |
title_full | Functional chlorin gold nanorods enable to treat breast cancer by photothermal/photodynamic therapy |
title_fullStr | Functional chlorin gold nanorods enable to treat breast cancer by photothermal/photodynamic therapy |
title_full_unstemmed | Functional chlorin gold nanorods enable to treat breast cancer by photothermal/photodynamic therapy |
title_short | Functional chlorin gold nanorods enable to treat breast cancer by photothermal/photodynamic therapy |
title_sort | functional chlorin gold nanorods enable to treat breast cancer by photothermal/photodynamic therapy |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278843/ https://www.ncbi.nlm.nih.gov/pubmed/30555230 http://dx.doi.org/10.2147/IJN.S186974 |
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