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Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study

Diet is a modifiable risk factor for several neoplasms but evidence for chronic lymphocytic leukemia (CLL) is sparse. Previous studies examining the association between single-food items and CLL risk have yielded mixed results, while few studies have been conducted on overall diet, reporting inconcl...

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Autores principales: Solans, Marta, Castelló, Adela, Benavente, Yolanda, Marcos-Gragera, Rafael, Amiano, Pilar, Gracia-Lavedan, Esther, Costas, Laura, Robles, Claudia, Gonzalez-Barca, Eva, de la Banda, Esmeralda, Alonso, Esther, Aymerich, Marta, Campo, Elias, Dierssen-Sotos, Trinidad, Fernández-Tardón, Guillermo, Olmedo-Requena, Rocio, Gimeno, Eva, Castaño-Vinyals, Gemma, Aragonés, Nuria, Kogevinas, Manolis, de Sanjose, Silvia, Pollán, Marina, Casabonne, Delphine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278961/
https://www.ncbi.nlm.nih.gov/pubmed/29954942
http://dx.doi.org/10.3324/haematol.2018.192526
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author Solans, Marta
Castelló, Adela
Benavente, Yolanda
Marcos-Gragera, Rafael
Amiano, Pilar
Gracia-Lavedan, Esther
Costas, Laura
Robles, Claudia
Gonzalez-Barca, Eva
de la Banda, Esmeralda
Alonso, Esther
Aymerich, Marta
Campo, Elias
Dierssen-Sotos, Trinidad
Fernández-Tardón, Guillermo
Olmedo-Requena, Rocio
Gimeno, Eva
Castaño-Vinyals, Gemma
Aragonés, Nuria
Kogevinas, Manolis
de Sanjose, Silvia
Pollán, Marina
Casabonne, Delphine
author_facet Solans, Marta
Castelló, Adela
Benavente, Yolanda
Marcos-Gragera, Rafael
Amiano, Pilar
Gracia-Lavedan, Esther
Costas, Laura
Robles, Claudia
Gonzalez-Barca, Eva
de la Banda, Esmeralda
Alonso, Esther
Aymerich, Marta
Campo, Elias
Dierssen-Sotos, Trinidad
Fernández-Tardón, Guillermo
Olmedo-Requena, Rocio
Gimeno, Eva
Castaño-Vinyals, Gemma
Aragonés, Nuria
Kogevinas, Manolis
de Sanjose, Silvia
Pollán, Marina
Casabonne, Delphine
author_sort Solans, Marta
collection PubMed
description Diet is a modifiable risk factor for several neoplasms but evidence for chronic lymphocytic leukemia (CLL) is sparse. Previous studies examining the association between single-food items and CLL risk have yielded mixed results, while few studies have been conducted on overall diet, reporting inconclusive findings. This study aimed to evaluate the association between adherence to three dietary patterns and CLL in the multicase-control study (MCC-Spain) study. Anthropometric, sociodemographic, medical and dietary information was collected for 369 CLL cases and 1605 controls. Three validated dietary patterns, Western, Prudent and Mediterranean, were reconstructed in the MCC-Spain data. The association between adherence to each dietary pattern and CLL was assessed, overall and by Rai stage, using mixed logistic regression models adjusted for potential confounders. High adherence to a Western dietary pattern (i.e. high intake of high-fat dairy products, processed meat, refined grains, sweets, caloric drinks, and convenience food) was associated with CLL [ORQ4 vs. Q1=1.63 (95%CI 1.11; 2.39); P-trend=0.02; OR 1-SD increase=1.19 (95%CI: 1.03; 1.37)], independently of Rai stages. No differences in the association were observed according to sex, Body Mass Index, energy intake, tobacco, physical activity, working on a farm, or family history of hematologic malignancies. No associations were observed for Mediterranean and Prudent dietary patterns and CLL. This study provides the first evidence for an association between a Western dietary pattern and CLL, suggesting that a proportion of CLL cases could be prevented by modifying dietary habits. Further research, especially with a prospective design, is warranted to confirm these findings.
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spelling pubmed-62789612018-12-13 Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study Solans, Marta Castelló, Adela Benavente, Yolanda Marcos-Gragera, Rafael Amiano, Pilar Gracia-Lavedan, Esther Costas, Laura Robles, Claudia Gonzalez-Barca, Eva de la Banda, Esmeralda Alonso, Esther Aymerich, Marta Campo, Elias Dierssen-Sotos, Trinidad Fernández-Tardón, Guillermo Olmedo-Requena, Rocio Gimeno, Eva Castaño-Vinyals, Gemma Aragonés, Nuria Kogevinas, Manolis de Sanjose, Silvia Pollán, Marina Casabonne, Delphine Haematologica Article Diet is a modifiable risk factor for several neoplasms but evidence for chronic lymphocytic leukemia (CLL) is sparse. Previous studies examining the association between single-food items and CLL risk have yielded mixed results, while few studies have been conducted on overall diet, reporting inconclusive findings. This study aimed to evaluate the association between adherence to three dietary patterns and CLL in the multicase-control study (MCC-Spain) study. Anthropometric, sociodemographic, medical and dietary information was collected for 369 CLL cases and 1605 controls. Three validated dietary patterns, Western, Prudent and Mediterranean, were reconstructed in the MCC-Spain data. The association between adherence to each dietary pattern and CLL was assessed, overall and by Rai stage, using mixed logistic regression models adjusted for potential confounders. High adherence to a Western dietary pattern (i.e. high intake of high-fat dairy products, processed meat, refined grains, sweets, caloric drinks, and convenience food) was associated with CLL [ORQ4 vs. Q1=1.63 (95%CI 1.11; 2.39); P-trend=0.02; OR 1-SD increase=1.19 (95%CI: 1.03; 1.37)], independently of Rai stages. No differences in the association were observed according to sex, Body Mass Index, energy intake, tobacco, physical activity, working on a farm, or family history of hematologic malignancies. No associations were observed for Mediterranean and Prudent dietary patterns and CLL. This study provides the first evidence for an association between a Western dietary pattern and CLL, suggesting that a proportion of CLL cases could be prevented by modifying dietary habits. Further research, especially with a prospective design, is warranted to confirm these findings. Ferrata Storti Foundation 2018-11 /pmc/articles/PMC6278961/ /pubmed/29954942 http://dx.doi.org/10.3324/haematol.2018.192526 Text en Copyright© 2018 Ferrata Storti Foundation Material published in Haematologica is covered by copyright. All rights are reserved to the Ferrata Storti Foundation. Use of published material is allowed under the following terms and conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode. Copies of published material are allowed for personal or internal use. Sharing published material for non-commercial purposes is subject to the following conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode, sect. 3. Reproducing and sharing published material for commercial purposes is not allowed without permission in writing from the publisher.
spellingShingle Article
Solans, Marta
Castelló, Adela
Benavente, Yolanda
Marcos-Gragera, Rafael
Amiano, Pilar
Gracia-Lavedan, Esther
Costas, Laura
Robles, Claudia
Gonzalez-Barca, Eva
de la Banda, Esmeralda
Alonso, Esther
Aymerich, Marta
Campo, Elias
Dierssen-Sotos, Trinidad
Fernández-Tardón, Guillermo
Olmedo-Requena, Rocio
Gimeno, Eva
Castaño-Vinyals, Gemma
Aragonés, Nuria
Kogevinas, Manolis
de Sanjose, Silvia
Pollán, Marina
Casabonne, Delphine
Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
title Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
title_full Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
title_fullStr Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
title_full_unstemmed Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
title_short Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
title_sort adherence to the western, prudent, and mediterranean dietary patterns and chronic lymphocytic leukemia in the mcc-spain study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278961/
https://www.ncbi.nlm.nih.gov/pubmed/29954942
http://dx.doi.org/10.3324/haematol.2018.192526
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