Novel lineage depletion preserves autologous blood stem cells for gene therapy of Fanconi anemia complementation group A

A hallmark of Fanconi anemia is accelerated decline in hematopoietic stem and progenitor cells (CD34 +) leading to bone marrow failure. Long-term treatment requires hematopoietic cell transplantation from an unaffected donor but is associated with potentially severe side-effects. Gene therapy to cor...

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Detalles Bibliográficos
Autores principales: Adair, Jennifer E., Chandrasekaran, Devikha, Sghia-Hughes, Gabriella, Haworth, Kevin G., Woolfrey, Ann E., Burroughs, Lauri M., Choi, Grace Y., Becker, Pamela S., Kiem, Hans-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278989/
https://www.ncbi.nlm.nih.gov/pubmed/29976742
http://dx.doi.org/10.3324/haematol.2018.194571

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