Cargando…
Gut microbiota diversity across ethnicities in the United States
Composed of hundreds of microbial species, the composition of the human gut microbiota can vary with chronic diseases underlying health disparities that disproportionally affect ethnic minorities. However, the influence of ethnicity on the gut microbiota remains largely unexplored and lacks reproduc...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279019/ https://www.ncbi.nlm.nih.gov/pubmed/30513082 http://dx.doi.org/10.1371/journal.pbio.2006842 |
_version_ | 1783378465162002432 |
---|---|
author | Brooks, Andrew W. Priya, Sambhawa Blekhman, Ran Bordenstein, Seth R. |
author_facet | Brooks, Andrew W. Priya, Sambhawa Blekhman, Ran Bordenstein, Seth R. |
author_sort | Brooks, Andrew W. |
collection | PubMed |
description | Composed of hundreds of microbial species, the composition of the human gut microbiota can vary with chronic diseases underlying health disparities that disproportionally affect ethnic minorities. However, the influence of ethnicity on the gut microbiota remains largely unexplored and lacks reproducible generalizations across studies. By distilling associations between ethnicity and differences in two US-based 16S gut microbiota data sets including 1,673 individuals, we report 12 microbial genera and families that reproducibly vary by ethnicity. Interestingly, a majority of these microbial taxa, including the most heritable bacterial family, Christensenellaceae, overlap with genetically associated taxa and form co-occurring clusters linked by similar fermentative and methanogenic metabolic processes. These results demonstrate recurrent associations between specific taxa in the gut microbiota and ethnicity, providing hypotheses for examining specific members of the gut microbiota as mediators of health disparities. |
format | Online Article Text |
id | pubmed-6279019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-62790192018-12-20 Gut microbiota diversity across ethnicities in the United States Brooks, Andrew W. Priya, Sambhawa Blekhman, Ran Bordenstein, Seth R. PLoS Biol Research Article Composed of hundreds of microbial species, the composition of the human gut microbiota can vary with chronic diseases underlying health disparities that disproportionally affect ethnic minorities. However, the influence of ethnicity on the gut microbiota remains largely unexplored and lacks reproducible generalizations across studies. By distilling associations between ethnicity and differences in two US-based 16S gut microbiota data sets including 1,673 individuals, we report 12 microbial genera and families that reproducibly vary by ethnicity. Interestingly, a majority of these microbial taxa, including the most heritable bacterial family, Christensenellaceae, overlap with genetically associated taxa and form co-occurring clusters linked by similar fermentative and methanogenic metabolic processes. These results demonstrate recurrent associations between specific taxa in the gut microbiota and ethnicity, providing hypotheses for examining specific members of the gut microbiota as mediators of health disparities. Public Library of Science 2018-12-04 /pmc/articles/PMC6279019/ /pubmed/30513082 http://dx.doi.org/10.1371/journal.pbio.2006842 Text en © 2018 Brooks et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Brooks, Andrew W. Priya, Sambhawa Blekhman, Ran Bordenstein, Seth R. Gut microbiota diversity across ethnicities in the United States |
title | Gut microbiota diversity across ethnicities in the United States |
title_full | Gut microbiota diversity across ethnicities in the United States |
title_fullStr | Gut microbiota diversity across ethnicities in the United States |
title_full_unstemmed | Gut microbiota diversity across ethnicities in the United States |
title_short | Gut microbiota diversity across ethnicities in the United States |
title_sort | gut microbiota diversity across ethnicities in the united states |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279019/ https://www.ncbi.nlm.nih.gov/pubmed/30513082 http://dx.doi.org/10.1371/journal.pbio.2006842 |
work_keys_str_mv | AT brooksandreww gutmicrobiotadiversityacrossethnicitiesintheunitedstates AT priyasambhawa gutmicrobiotadiversityacrossethnicitiesintheunitedstates AT blekhmanran gutmicrobiotadiversityacrossethnicitiesintheunitedstates AT bordensteinsethr gutmicrobiotadiversityacrossethnicitiesintheunitedstates |