MDR1 in immunity: friend or foe?

MDR1 is an ATP-dependent transmembrane transporter primarily studied for its role in the detoxification of tissues and for its implication in resistance of tumor cells to chemotherapy treatment. Several studies also report on its expression on immune cells where it plays a protective role from xenob...

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Detalles Bibliográficos
Autores principales: Bossennec, Marion, Di Roio, Anthony, Caux, Christophe, Ménétrier-Caux, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279327/
https://www.ncbi.nlm.nih.gov/pubmed/30524890
http://dx.doi.org/10.1080/2162402X.2018.1499388
Descripción
Sumario:MDR1 is an ATP-dependent transmembrane transporter primarily studied for its role in the detoxification of tissues and for its implication in resistance of tumor cells to chemotherapy treatment. Several studies also report on its expression on immune cells where it plays a protective role from xenobiotics and toxins. This review provides an overview of what is known on MDR1 expression in immune cells in human, and its implications in different pathologies and their treatment options.

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