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The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner
The Toll pathway regulates the cellular response to infection via the transcriptional upregulation of antimicrobial peptides. In Drosophila, apart from its role in innate immunity, this pathway has also been reported to be important for the elimination of loser cells in a process referred to as cell...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279345/ https://www.ncbi.nlm.nih.gov/pubmed/30451683 http://dx.doi.org/10.7554/eLife.39939 |
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author | Germani, Federico Hain, Daniel Sternlicht, Denise Moreno, Eduardo Basler, Konrad |
author_facet | Germani, Federico Hain, Daniel Sternlicht, Denise Moreno, Eduardo Basler, Konrad |
author_sort | Germani, Federico |
collection | PubMed |
description | The Toll pathway regulates the cellular response to infection via the transcriptional upregulation of antimicrobial peptides. In Drosophila, apart from its role in innate immunity, this pathway has also been reported to be important for the elimination of loser cells in a process referred to as cell competition, which can be locally triggered by secreted factors released from winner cells. In this work, we provide evidence that the inhibition of Toll signaling not only increases the fitness of loser cells, but also bestows a clonal growth advantage on wild-type cells. We further demonstrate that this growth advantage depends on basal infection levels since it is no longer present under axenic conditions but exacerbated upon intense pathogen exposure. Thus, the Toll pathway functions as a fine-tuned pro-apoptotic and anti-proliferative regulator, underlining the existence of a trade-off between innate immunity and growth during development. |
format | Online Article Text |
id | pubmed-6279345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-62793452018-12-05 The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner Germani, Federico Hain, Daniel Sternlicht, Denise Moreno, Eduardo Basler, Konrad eLife Developmental Biology The Toll pathway regulates the cellular response to infection via the transcriptional upregulation of antimicrobial peptides. In Drosophila, apart from its role in innate immunity, this pathway has also been reported to be important for the elimination of loser cells in a process referred to as cell competition, which can be locally triggered by secreted factors released from winner cells. In this work, we provide evidence that the inhibition of Toll signaling not only increases the fitness of loser cells, but also bestows a clonal growth advantage on wild-type cells. We further demonstrate that this growth advantage depends on basal infection levels since it is no longer present under axenic conditions but exacerbated upon intense pathogen exposure. Thus, the Toll pathway functions as a fine-tuned pro-apoptotic and anti-proliferative regulator, underlining the existence of a trade-off between innate immunity and growth during development. eLife Sciences Publications, Ltd 2018-11-19 /pmc/articles/PMC6279345/ /pubmed/30451683 http://dx.doi.org/10.7554/eLife.39939 Text en © 2018, Germani et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology Germani, Federico Hain, Daniel Sternlicht, Denise Moreno, Eduardo Basler, Konrad The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner |
title | The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner |
title_full | The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner |
title_fullStr | The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner |
title_full_unstemmed | The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner |
title_short | The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner |
title_sort | toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner |
topic | Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279345/ https://www.ncbi.nlm.nih.gov/pubmed/30451683 http://dx.doi.org/10.7554/eLife.39939 |
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