Pore- and voltage sensor–targeted KCNQ openers have distinct state-dependent actions

Ion channels encoded by KCNQ2-5 generate a prominent K(+) conductance in the central nervous system, referred to as the M current, which is controlled by membrane voltage and PIP2. The KCNQ2-5 voltage-gated potassium channels are targeted by a variety of activating compounds that cause negative shif...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Caroline K., Lamothe, Shawn M., Wang, Alice W., Yang, Runying Y., Kurata, Harley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279353/
https://www.ncbi.nlm.nih.gov/pubmed/30373787
http://dx.doi.org/10.1085/jgp.201812070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279353/
https://www.ncbi.nlm.nih.gov/pubmed/30373787
http://dx.doi.org/10.1085/jgp.201812070

Ejemplares similares