Wrapping up the fats—a structure of the lipid droplet biogenesis protein seipin

The lipid droplet (LD) biogenesis protein seipin is crucial for formation of normal LDs, but its exact functional role has been enigmatic. In this issue, Sui et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201809067) report the cryo­–electron microscopy structure of seipin, which provides no...

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Detalles Bibliográficos
Autor principal: Bohnert, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279380/
https://www.ncbi.nlm.nih.gov/pubmed/30442641
http://dx.doi.org/10.1083/jcb.201811021
Descripción
Sumario:The lipid droplet (LD) biogenesis protein seipin is crucial for formation of normal LDs, but its exact functional role has been enigmatic. In this issue, Sui et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201809067) report the cryo­–electron microscopy structure of seipin, which provides novel insights into how seipin might mediate LD formation.

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