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Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies

SRPK2 is abnormally activated in tauopathies including Alzheimer’s disease (AD). SRPK2 is known to play an important role in pre–mRNA splicing by phosphorylating SR-splicing factors. Dysregulation of tau exon 10 pre–mRNA splicing causes pathological imbalances in 3R- and 4R-tau, leading to neurodege...

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Detalles Bibliográficos
Autores principales:	Wang, Zhi-Hao, Liu, Pai, Liu, Xia, Yu, Shan Ping, Wang, Jian-Zhi, Ye, Keqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279401/ https://www.ncbi.nlm.nih.gov/pubmed/30373880 http://dx.doi.org/10.1084/jem.20180539

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