PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia

The tendency of mitochondria to undergo or resist BCL2-controlled apoptosis (so-called mitochondrial priming) is a powerful predictor of response to cytotoxic chemotherapy. Fully exploiting this finding will require unraveling the molecular genetics underlying phenotypic variability in mitochondrial...

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Detalles Bibliográficos
Autores principales: Ariës, Ingrid M., Bodaar, Kimberly, Karim, Salmaan A., Chonghaile, Triona Ni, Hinze, Laura, Burns, Melissa A., Pfirrmann, Maren, Degar, James, Landrigan, Jack T., Balbach, Sebastian, Peirs, Sofie, Menten, Björn, Isenhart, Randi, Stevenson, Kristen E., Neuberg, Donna S., Devidas, Meenakshi, Loh, Mignon L., Hunger, Stephen P., Teachey, David T., Rabin, Karen R., Winter, Stuart S., Dunsmore, Kimberly P., Wood, Brent L., Silverman, Lewis B., Sallan, Stephen E., Van Vlierberghe, Pieter, Orkin, Stuart H., Knoechel, Birgit, Letai, Anthony G., Gutierrez, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279404/
https://www.ncbi.nlm.nih.gov/pubmed/30404791
http://dx.doi.org/10.1084/jem.20180570

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