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PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt

Phosphatidylinositol-3 kinases (PI3Ks) modulate cellular growth, proliferation, and survival; dysregulation of the PI3K pathway can lead to autoimmune disease and cancer. PIK3IP1 (or transmembrane inhibitor of PI3K [TrIP]) is a putative transmembrane regulator of PI3K. TrIP contains an extracellular...

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Detalles Bibliográficos
Autores principales:	Uche, Uzodinma U., Piccirillo, Ann R., Kataoka, Shunsuke, Grebinoski, Stephanie J., D’Cruz, Louise M., Kane, Lawrence P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279406/ https://www.ncbi.nlm.nih.gov/pubmed/30429249 http://dx.doi.org/10.1084/jem.20172018

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