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TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG

Toll-like receptors (TLRs) are nucleic acid–sensing receptors and have been implicated in mediating pain and itch. Here we report that Tlr8(−/−) mice show normal itch behaviors, but have defects in neuropathic pain induced by spinal nerve ligation (SNL) in mice. SNL increased TLR8 expression in smal...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhi-Jun, Guo, Jian-Shuang, Li, Si-Si, Wu, Xiao-Bo, Cao, De-Li, Jiang, Bao-Chun, Jing, Peng-Bo, Bai, Xue-Qiang, Li, Chun-Hua, Wu, Zi-Han, Lu, Ying, Gao, Yong-Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279408/ https://www.ncbi.nlm.nih.gov/pubmed/30455267 http://dx.doi.org/10.1084/jem.20180800

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