Low-dose cyclophosphamide depletes circulating naïve and activated regulatory T cells in malignant pleural mesothelioma patients synergistically treated with dendritic cell-based immunotherapy

Rationale: Regulatory T cells (Treg) play a pivotal role in the immunosuppressive tumor micro-environment in cancer, including mesothelioma. Recently, the combination of autologous tumor lysate-pulsed dendritic cells (DC) and metronomic cyclophosphamide (mCTX) was reported as a feasible and well-tol...

Descripción completa

Detalles Bibliográficos
Autores principales: Noordam, Lisanne, Kaijen, Margaretha E.H., Bezemer, Koen, Cornelissen, Robin, Maat, Lex A.P.W.M., Hoogsteden, Henk C., Aerts, Joachim G.J.V., Hendriks, Rudi W., Hegmans, Joost P.J.J, Vroman, Heleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279421/
https://www.ncbi.nlm.nih.gov/pubmed/30524884
http://dx.doi.org/10.1080/2162402X.2018.1474318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279421/
https://www.ncbi.nlm.nih.gov/pubmed/30524884
http://dx.doi.org/10.1080/2162402X.2018.1474318

Ejemplares similares