Cargando…

Low-dose cyclophosphamide depletes circulating naïve and activated regulatory T cells in malignant pleural mesothelioma patients synergistically treated with dendritic cell-based immunotherapy

Rationale: Regulatory T cells (Treg) play a pivotal role in the immunosuppressive tumor micro-environment in cancer, including mesothelioma. Recently, the combination of autologous tumor lysate-pulsed dendritic cells (DC) and metronomic cyclophosphamide (mCTX) was reported as a feasible and well-tol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Noordam, Lisanne, Kaijen, Margaretha E.H., Bezemer, Koen, Cornelissen, Robin, Maat, Lex A.P.W.M., Hoogsteden, Henk C., Aerts, Joachim G.J.V., Hendriks, Rudi W., Hegmans, Joost P.J.J, Vroman, Heleen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279421/ https://www.ncbi.nlm.nih.gov/pubmed/30524884 http://dx.doi.org/10.1080/2162402X.2018.1474318

Ejemplares similares

COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function
por: Veltman, Joris D, et al.
Publicado: (2010)

Tumour-derived exosomes as antigen delivery carriers in dendritic cell-based immunotherapy for malignant mesothelioma
por: Mahaweni, Niken M., et al.
Publicado: (2013)

Ratio of Intratumoral Macrophage Phenotypes Is a Prognostic Factor in Epithelioid Malignant Pleural Mesothelioma
por: Cornelissen, Robin, et al.
Publicado: (2014)

New Roads Open Up for Implementing Immunotherapy in Mesothelioma
por: Cornelissen, R., et al.
Publicado: (2012)

Immunological profiling as a means to invigorate personalized cancer therapy
por: Hegmans, Joost PJJ, et al.
Publicado: (2013)

Low-Dose Cyclophosphamide Synergizes with Dendritic Cell-Based Immunotherapy in Antitumor Activity
por: Veltman, Joris D., et al.
Publicado: (2010)

Autologous Dendritic Cell Therapy in Mesothelioma Patients Enhances Frequencies of Peripheral CD4 T Cells Expressing HLA-DR, PD-1, or ICOS
por: de Goeje, Pauline L., et al.
Publicado: (2018)

Heterogeneity in Immune Cell Content in Malignant Pleural Mesothelioma
por: Minnema-Luiting, Jorien, et al.
Publicado: (2018)

Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma
por: Veltman, J D, et al.
Publicado: (2010)

T cell receptor repertoire characteristics both before and following immunotherapy correlate with clinical response in mesothelioma
por: Vroman, Heleen, et al.
Publicado: (2020)

Efficacy of nivolumab and ipilimumab in patients with malignant pleural mesothelioma is related to a subtype of effector memory cytotoxic T cells: Translational evidence from two clinical trials
por: Mankor, Joanne M., et al.
Publicado: (2020)

Immune monitoring in mesothelioma patients identifies novel immune-modulatory functions of gemcitabine associating with clinical response
por: Dammeijer, Floris, et al.
Publicado: (2021)

Enhancing Dendritic Cell Therapy in Solid Tumors with Immunomodulating Conventional Treatment
por: Belderbos, Robert A., et al.
Publicado: (2019)

Cellular Immunotherapy and Locoregional Administration of CAR T-Cells in Malignant Pleural Mesothelioma
por: Belderbos, Robert A., et al.
Publicado: (2020)

Dendritic Cell Subsets in Asthma: Impaired Tolerance or Exaggerated Inflammation?
por: Vroman, Heleen, et al.
Publicado: (2017)

Patient-tailored modulation of the immune system may revolutionize future lung cancer treatment
por: Heuvers, Marlies E, et al.
Publicado: (2012)

Long-Term Follow-Up of Mesothelioma Patients Treated with Dendritic Cell Therapy in Three Phase I/II Trials
por: Dumoulin, Daphne W., et al.
Publicado: (2021)

Improved diagnosis and prognostication of patients with pleural malignant mesothelioma using biomarkers in pleural effusions and peripheral blood samples – a short report
por: Beije, Nick, et al.
Publicado: (2017)

Ki67 (MIB-1) as a Prognostic Marker for Clinical Decision Making Before Extended Pleurectomy Decortication in Malignant Pleural Mesothelioma
por: Belderbos, Robert A., et al.
Publicado: (2021)

Rare thoracic cancers: a comprehensive overview of diagnosis and management of small cell lung cancer, malignant pleural mesothelioma and thymic epithelial tumours
por: Dumoulin, Daphne W., et al.
Publicado: (2023)

Combination of PD‐1/PD‐L1 checkpoint inhibition and dendritic cell therapy in mice models and in patients with mesothelioma
por: van Gulijk, Mandy, et al.
Publicado: (2022)

Current State of Dendritic Cell-Based Immunotherapy: Opportunities for in vitro Antigen Loading of Different DC Subsets?
por: Huber, Anne, et al.
Publicado: (2018)

Combination Strategies to Optimize Efficacy of Dendritic Cell-Based Immunotherapy
por: van Gulijk, Mandy, et al.
Publicado: (2018)

Prediction of response to pemetrexed in non-small-cell lung cancer with immunohistochemical phenotyping based on gene expression profiles
por: Visser, S., et al.
Publicado: (2019)

Incidence, treatment and survival of malignant pleural and peritoneal mesothelioma: a population-based study
por: van Kooten, Job P, et al.
Publicado: (2022)

Towards the Optical Detection of Field Cancerization in the Buccal Mucosa of Patients with Lung Cancer()()
por: Bugter, O., et al.
Publicado: (2019)

PD-L1(+) lung cancer stem cells modify the metastatic lymph-node immunomicroenvironment in nsclc patients
por: Raniszewska, A., et al.
Publicado: (2020)

Nivolumab in pre-treated malignant pleural mesothelioma: real-world data from the Dutch expanded access program
por: Cantini, Luca, et al.
Publicado: (2020)

Granuloma Formation in Pulmonary Sarcoidosis
por: Broos, Caroline E., et al.
Publicado: (2013)

Cardio-abdominal echinococcosis: A man with a visible pulsating abdominal mass
por: Jainandunsing, S., et al.
Publicado: (2017)

Peritoneal mesothelioma.
por: Kealey, W. D., et al.
Publicado: (1993)

Bronchiolitis obliterans organizing pneumonia (BOOP) after thoracic radiotherapy for breast carcinoma
por: Cornelissen, Robin, et al.
Publicado: (2007)

Evaluation of Clinical and Immunological Responses: A 2-Year Follow-Up Study in Children with Allergic Rhinitis due to House Dust Mite
por: Moed, Heleen, et al.
Publicado: (2013)

Group 2 Innate Lymphoid Cells Exhibit a Dynamic Phenotype in Allergic Airway Inflammation
por: Li, Bobby W. S., et al.
Publicado: (2017)

Emerging Treatments for Malignant Pleural Mesothelioma: Where Are We Heading?
por: Cantini, Luca, et al.
Publicado: (2020)

Tnfaip3 expression in pulmonary conventional type 1 Langerin‐expressing dendritic cells regulates T helper 2‐mediated airway inflammation in mice
por: Vroman, Heleen, et al.
Publicado: (2020)

Improving lung cancer survival; time to move on
por: Heuvers, Marlies E, et al.
Publicado: (2012)

Paternal Cyclophosphamide Exposure Induces the Formation of Functional Micronuclei during the First Zygotic Division
por: Grenier, Lisanne, et al.
Publicado: (2011)

Type-2 CD8(+) T-cell formation relies on interleukin-33 and is linked to asthma exacerbations
por: van der Ploeg, Esmee K., et al.
Publicado: (2023)

Evidence for local dendritic cell activation in pulmonary sarcoidosis
por: Berge, Bregje Ten, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_2vvt9g1j4aq7bsveraq8hg88qo