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Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1

The mammalian cochlea contains two types of mechanosensory hair cells (HCs) that play different and critical roles in hearing. Inner hair cells (IHCs), with an elaborate presynaptic apparatus, signal to cochlear neurons and communicate sound information to the brain. Outer hair cells (OHCs) mechanic...

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Detalles Bibliográficos
Autores principales: Wiwatpanit, Teerawat, Lorenzen, Sarah M., Cantú, Jorge A., Foo, Chuan Zhi, Hogan, Ann K., Márquez, Freddie, Clancy, John C., Schipma, Matthew J., Cheatham, Mary Ann, Duggan, Anne, García-Añoveros, Jaime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279423/
https://www.ncbi.nlm.nih.gov/pubmed/30305733
http://dx.doi.org/10.1038/s41586-018-0570-8