Antigen-specificity and DTIC before peptide-vaccination differently shape immune-checkpoint expression pattern, anti-tumor functionality and TCR repertoire in melanoma patients

We have recently described that DNA-damage inducing drug DTIC, administered before peptide (Melan-A and gp100)-vaccination, improves anti-tumor CD8(+) Melan-A-specific T-cell functionality, enlarges the Melan-A(+) TCR repertoire and impacts the overall survival of melanoma patients. To identify whet...

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Detalles Bibliográficos
Autores principales: Palermo, Belinda, Franzese, Ornella, Donna, Cosmo Di, Panetta, Mariangela, Quintarelli, Concetta, Sperduti, Isabella, Gualtieri, Novella, Foddai, Maria Laura, Proietti, Enrico, Ferraresi, Virginia, Ciliberto, Gennaro, Nisticò, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279427/
https://www.ncbi.nlm.nih.gov/pubmed/30524882
http://dx.doi.org/10.1080/2162402X.2018.1465163

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