Cargando…

A near atomic-scale view at the composition of amyloid-beta fibrils by atom probe tomography

Amyloid-beta (Ab) proteins play an important role in a number of neurodegenerative diseases. Ab is found in senile plaques in brains of Alzeimer’s disease patients. The 42 residues of the monomer form dimers which stack to fibrils gaining several micrometers in length. Using Ab fibrils with (13)C an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rusitzka, Kristiane A. K., Stephenson, Leigh T., Szczepaniak, Agnieszka, Gremer, Lothar, Raabe, Dierk, Willbold, Dieter, Gault, Baptiste
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279744/ https://www.ncbi.nlm.nih.gov/pubmed/30514971 http://dx.doi.org/10.1038/s41598-018-36110-y

Ejemplares similares

The Laplace Project: An integrated suite for preparing and transferring atom probe samples under cryogenic and UHV conditions
por: Stephenson, Leigh T., et al.
Publicado: (2018)

Laser-equipped gas reaction chamber for probing environmentally sensitive materials at near atomic scale
por: Khanchandani, Heena, et al.
Publicado: (2022)

Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy
por: Röder, Christine, et al.
Publicado: (2019)

Atomic Resolution Insights into pH Shift Induced Deprotonation Events in LS-Shaped Aβ(1–42) Amyloid Fibrils
por: Becker, Nina, et al.
Publicado: (2023)

Hydrogen and deuterium charging of lifted-out specimens for atom probe tomography
por: Khanchandani, Heena, et al.
Publicado: (2022)

Atomic motifs govern the decoration of grain boundaries by interstitial solutes
por: Zhou, Xuyang, et al.
Publicado: (2023)

Interstitial atoms enable joint twinning and transformation induced plasticity in strong and ductile high-entropy alloys
por: Li, Zhiming, et al.
Publicado: (2017)

Atom probe analysis of electrode materials for Li-ion batteries: challenges and ways forward
por: Kim, Se-Ho, et al.
Publicado: (2022)

Enabling near-atomic–scale analysis of frozen water
por: El-Zoka, A. A., et al.
Publicado: (2020)

Discovery and Implications of Hidden Atomic-Scale Structure in a Metallic Meteorite
por: Kovács, András, et al.
Publicado: (2021)

The Fate of Water in Hydrogen‐Based Iron Oxide Reduction
por: El‐Zoka, Ayman A., et al.
Publicado: (2023)

Spinodal decomposition in alkali feldspar studied by atom probe tomography
por: Petrishcheva, Elena, et al.
Publicado: (2020)

Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy
por: Dammers, Christina, et al.
Publicado: (2015)

β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor
por: Mirecka, Ewa A., et al.
Publicado: (2016)

Understanding the Degradation of a Model Si Anode in a Li-Ion Battery at the Atomic Scale
por: Kim, Se-Ho, et al.
Publicado: (2022)

Origin of metastable oligomers and their effects on amyloid fibril self-assembly
por: Hasecke, Filip, et al.
Publicado: (2018)

New approach for FIB-preparation of atom probe specimens for aluminum alloys
por: Lilensten, L., et al.
Publicado: (2020)

Met/Val129 polymorphism of the full-length human prion protein dictates distinct pathways of amyloid formation
por: Pauly, Thomas, et al.
Publicado: (2022)

Point-by-point compositional analysis for atom probe tomography
por: Stephenson, Leigh T., et al.
Publicado: (2014)

Atomic‐Scale Mapping of Impurities in Partially Reduced Hollow TiO(2) Nanowires
por: Lim, Joohyun, et al.
Publicado: (2020)

Open and strong-scaling tools for atom-probe crystallography: high-throughput methods for indexing crystal structure and orientation
por: Kühbach, Markus, et al.
Publicado: (2021)

Substantially enhanced plasticity of bulk metallic glasses by densifying local atomic packing
por: Wu, Yuan, et al.
Publicado: (2021)

Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth
por: Wördehoff, Michael M., et al.
Publicado: (2017)

Quantitative three-dimensional imaging of chemical short-range order via machine learning enhanced atom probe tomography
por: Li, Yue, et al.
Publicado: (2023)

Revisiting stress-corrosion cracking and hydrogen embrittlement in 7xxx-Al alloys at the near-atomic-scale
por: López Freixes, Martí, et al.
Publicado: (2022)

3D nanostructural characterisation of grain boundaries in atom probe data utilising machine learning methods
por: Wei, Ye, et al.
Publicado: (2019)

Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy
por: König, Anna S., et al.
Publicado: (2021)

Cryo-focused ion beam preparation of perovskite based solar cells for atom probe tomography
por: Rivas, Nicolás Alfonso, et al.
Publicado: (2020)

Atomic resolution dynamics on the surface of amyloid β protofibrils probed by solution NMR
por: Fawzi, Nicolas L., et al.
Publicado: (2011)

Interpreting nanovoids in atom probe tomography data for accurate local compositional measurements
por: Wang, Xing, et al.
Publicado: (2020)

Analysis at the Atomic Level: The Atom Probe Field-Ion Microscope
por: Miller, M. K.
Publicado: (1988)

Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin
por: Törner, Ricarda, et al.
Publicado: (2022)

Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity
por: Rudolph, Stephan, et al.
Publicado: (2016)

Correlating advanced microscopies reveals atomic-scale mechanisms limiting lithium-ion battery lifetime
por: Gault, Baptiste, et al.
Publicado: (2021)

Atom-smashers for Europe near
Publicado: (1953)

Correction: Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity
por: Rudolph, Stephan, et al.
Publicado: (2016)

Atomic-Resolution Three-Dimensional Structure of Amyloid β Fibrils Bearing the Osaka Mutation**
por: Schütz, Anne K, et al.
Publicado: (2015)

Superthermal Al Atoms as a Reactive-Atom Probe of Fluorinated Surfaces
por: Lane, Paul D., et al.
Publicado: (2023)

Atomic Scale Origin of Metal Ion Release from Hip Implant Taper Junctions
por: Balachandran, Shanoob, et al.
Publicado: (2020)

Author Correction: Correlating advanced microscopies reveals atomic-scale mechanisms limiting lithium-ion battery lifetime
por: Gault, Baptiste, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lvo36r86fjqcrmel2plj9uaon0