Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging

To understand the molecular features underlying stem cell aging, we established intestinal epithelial organoids derived from both young and aged mice and investigated alterations in their senescence and epigenetic status. Senescence-related changes including accumulation of senescence-associated β-g...

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Detalles Bibliográficos
Autores principales: Uchida, Ryoei, Saito, Yoshimasa, Nogami, Kazuki, Kajiyama, Yohei, Suzuki, Yukana, Kawase, Yasuhiro, Nakaoka, Toshiaki, Muramatsu, Toshihide, Kimura, Masaki, Saito, Hidetsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279747/
https://www.ncbi.nlm.nih.gov/pubmed/30534415
http://dx.doi.org/10.1038/s41514-018-0031-5

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