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Computational affinity maturation of camelid single-domain intrabodies against the nonamyloid component of alpha-synuclein
Improving the affinity of protein-protein interactions is a challenging problem that is particularly important in the development of antibodies for diagnostic and clinical use. Here, we used structure-based computational methods to optimize the binding affinity of V(H)NAC1, a single-domain intracell...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279780/ https://www.ncbi.nlm.nih.gov/pubmed/30514850 http://dx.doi.org/10.1038/s41598-018-35464-7 |