IL-6 and the dysregulation of immune, bone, muscle, and metabolic homeostasis during spaceflight

We have previously reported that exercise-related secretion of IL-6 by peripheral blood mononuclear cells is proportionate to body weight, suggesting that IL-6 is gravisensitive and that suboptimal production of this key cytokine may contribute to homeostatic dysregulations that occur during spacefl...

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Autor principal: Smith, John Kelly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279793/
https://www.ncbi.nlm.nih.gov/pubmed/30534586
http://dx.doi.org/10.1038/s41526-018-0057-9
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author Smith, John Kelly
author_facet Smith, John Kelly
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description We have previously reported that exercise-related secretion of IL-6 by peripheral blood mononuclear cells is proportionate to body weight, suggesting that IL-6 is gravisensitive and that suboptimal production of this key cytokine may contribute to homeostatic dysregulations that occur during spaceflight. This review details what is known about the role of this key cytokine in innate and adaptive immunity, hematopoiesis, and in bone, muscle and metabolic homeostasis on Earth and in the microgravity of space and suggests an experimental approach to confirm or disavow the role of IL-6 in space-related dysregulations.
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spelling pubmed-62797932018-12-10 IL-6 and the dysregulation of immune, bone, muscle, and metabolic homeostasis during spaceflight Smith, John Kelly NPJ Microgravity Review Article We have previously reported that exercise-related secretion of IL-6 by peripheral blood mononuclear cells is proportionate to body weight, suggesting that IL-6 is gravisensitive and that suboptimal production of this key cytokine may contribute to homeostatic dysregulations that occur during spaceflight. This review details what is known about the role of this key cytokine in innate and adaptive immunity, hematopoiesis, and in bone, muscle and metabolic homeostasis on Earth and in the microgravity of space and suggests an experimental approach to confirm or disavow the role of IL-6 in space-related dysregulations. Nature Publishing Group UK 2018-12-04 /pmc/articles/PMC6279793/ /pubmed/30534586 http://dx.doi.org/10.1038/s41526-018-0057-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Smith, John Kelly
IL-6 and the dysregulation of immune, bone, muscle, and metabolic homeostasis during spaceflight
title IL-6 and the dysregulation of immune, bone, muscle, and metabolic homeostasis during spaceflight
title_full IL-6 and the dysregulation of immune, bone, muscle, and metabolic homeostasis during spaceflight
title_fullStr IL-6 and the dysregulation of immune, bone, muscle, and metabolic homeostasis during spaceflight
title_full_unstemmed IL-6 and the dysregulation of immune, bone, muscle, and metabolic homeostasis during spaceflight
title_short IL-6 and the dysregulation of immune, bone, muscle, and metabolic homeostasis during spaceflight
title_sort il-6 and the dysregulation of immune, bone, muscle, and metabolic homeostasis during spaceflight
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279793/
https://www.ncbi.nlm.nih.gov/pubmed/30534586
http://dx.doi.org/10.1038/s41526-018-0057-9
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