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Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice

Within the mammalian olfactory sensory epithelium, experience-dependent changes in the rate of neuronal turnover can alter the relative abundance of neurons expressing specific chemoreceptors. Here we investigate how the mouse olfactory sensory receptor repertoire changes as a function of exposure t...

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Autores principales: van der Linden, Carl, Jakob, Susanne, Gupta, Pooja, Dulac, Catherine, Santoro, Stephen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279840/
https://www.ncbi.nlm.nih.gov/pubmed/30514924
http://dx.doi.org/10.1038/s41467-018-07120-1
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author van der Linden, Carl
Jakob, Susanne
Gupta, Pooja
Dulac, Catherine
Santoro, Stephen W.
author_facet van der Linden, Carl
Jakob, Susanne
Gupta, Pooja
Dulac, Catherine
Santoro, Stephen W.
author_sort van der Linden, Carl
collection PubMed
description Within the mammalian olfactory sensory epithelium, experience-dependent changes in the rate of neuronal turnover can alter the relative abundance of neurons expressing specific chemoreceptors. Here we investigate how the mouse olfactory sensory receptor repertoire changes as a function of exposure to odors emitted from members of the opposite sex, which are highly complex and sexually dimorphic. Upon housing mice either sex-separated or sex-combined until six months of age, we find that sex-separated mice exhibit significantly more numerous differentially expressed genes within their olfactory epithelia. A subset of these chemoreceptors exhibit altered expression frequencies following both sex-separation and olfactory deprivation. We show that several of these receptors detect either male- or female-specific odors. We conclude that the distinct odor experiences of sex-separated male and female mice induce sex-specific differences in the abundance of neurons that detect sexually dimorphic odors.
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spelling pubmed-62798402018-12-06 Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice van der Linden, Carl Jakob, Susanne Gupta, Pooja Dulac, Catherine Santoro, Stephen W. Nat Commun Article Within the mammalian olfactory sensory epithelium, experience-dependent changes in the rate of neuronal turnover can alter the relative abundance of neurons expressing specific chemoreceptors. Here we investigate how the mouse olfactory sensory receptor repertoire changes as a function of exposure to odors emitted from members of the opposite sex, which are highly complex and sexually dimorphic. Upon housing mice either sex-separated or sex-combined until six months of age, we find that sex-separated mice exhibit significantly more numerous differentially expressed genes within their olfactory epithelia. A subset of these chemoreceptors exhibit altered expression frequencies following both sex-separation and olfactory deprivation. We show that several of these receptors detect either male- or female-specific odors. We conclude that the distinct odor experiences of sex-separated male and female mice induce sex-specific differences in the abundance of neurons that detect sexually dimorphic odors. Nature Publishing Group UK 2018-12-04 /pmc/articles/PMC6279840/ /pubmed/30514924 http://dx.doi.org/10.1038/s41467-018-07120-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
van der Linden, Carl
Jakob, Susanne
Gupta, Pooja
Dulac, Catherine
Santoro, Stephen W.
Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice
title Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice
title_full Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice
title_fullStr Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice
title_full_unstemmed Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice
title_short Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice
title_sort sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279840/
https://www.ncbi.nlm.nih.gov/pubmed/30514924
http://dx.doi.org/10.1038/s41467-018-07120-1
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