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Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism
BACKGROUND: Increasing evidence supports interplay between aldosterone and parathyroid hormone (PTH), which may aggravate cardiovascular complications in various heart diseases. Negative structural cardiovascular remodeling by primary aldosteronism (PA) is also suspected to be associated with change...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Endocrine Society
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279903/ https://www.ncbi.nlm.nih.gov/pubmed/30513563 http://dx.doi.org/10.3803/EnM.2018.33.4.485 |
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author | Lim, Jung Soo Hong, Namki Park, Sungha Park, Sung Il Oh, Young Taik Yu, Min Heui Lim, Pil Yong Rhee, Yumie |
author_facet | Lim, Jung Soo Hong, Namki Park, Sungha Park, Sung Il Oh, Young Taik Yu, Min Heui Lim, Pil Yong Rhee, Yumie |
author_sort | Lim, Jung Soo |
collection | PubMed |
description | BACKGROUND: Increasing evidence supports interplay between aldosterone and parathyroid hormone (PTH), which may aggravate cardiovascular complications in various heart diseases. Negative structural cardiovascular remodeling by primary aldosteronism (PA) is also suspected to be associated with changes in calcium levels. However, to date, few clinical studies have examined how changes in calcium and PTH levels influence cardiovascular outcomes in PA patients. Therefore, we investigated the impact of altered calcium homeostasis caused by excessive aldosterone on cardiovascular parameters in patients with PA. METHODS: Forty-two patients (mean age 48.8±10.9 years; 1:1, male:female) whose plasma aldosterone concentration/plasma renin activity ratio was more than 30 were selected among those who had visited Severance Hospital from 2010 to 2014. All patients underwent adrenal venous sampling with complete access to both adrenal veins. RESULTS: The prevalence of unilateral adrenal adenoma (54.8%) was similar to that of bilateral adrenal hyperplasia. Mean serum corrected calcium level was 8.9±0.3 mg/dL (range, 8.3 to 9.9). The corrected calcium level had a negative linear correlation with left ventricular end-diastolic diameter (LVEDD, ρ=−0.424, P=0.031). Moreover, multivariable regression analysis showed that the corrected calcium level was marginally associated with the LVEDD and corrected QT (QTc) interval (β=−0.366, P=0.068 and β=−0.252, P=0.070, respectively). CONCLUSION: Aldosterone-mediated hypercalciuria and subsequent hypocalcemia may be partly involved in the development of cardiac remodeling as well as a prolonged QTc interval, in subjects with PA, thereby triggering deleterious effects on target organs additively. |
format | Online Article Text |
id | pubmed-6279903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Endocrine Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-62799032018-12-13 Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism Lim, Jung Soo Hong, Namki Park, Sungha Park, Sung Il Oh, Young Taik Yu, Min Heui Lim, Pil Yong Rhee, Yumie Endocrinol Metab (Seoul) Original Article BACKGROUND: Increasing evidence supports interplay between aldosterone and parathyroid hormone (PTH), which may aggravate cardiovascular complications in various heart diseases. Negative structural cardiovascular remodeling by primary aldosteronism (PA) is also suspected to be associated with changes in calcium levels. However, to date, few clinical studies have examined how changes in calcium and PTH levels influence cardiovascular outcomes in PA patients. Therefore, we investigated the impact of altered calcium homeostasis caused by excessive aldosterone on cardiovascular parameters in patients with PA. METHODS: Forty-two patients (mean age 48.8±10.9 years; 1:1, male:female) whose plasma aldosterone concentration/plasma renin activity ratio was more than 30 were selected among those who had visited Severance Hospital from 2010 to 2014. All patients underwent adrenal venous sampling with complete access to both adrenal veins. RESULTS: The prevalence of unilateral adrenal adenoma (54.8%) was similar to that of bilateral adrenal hyperplasia. Mean serum corrected calcium level was 8.9±0.3 mg/dL (range, 8.3 to 9.9). The corrected calcium level had a negative linear correlation with left ventricular end-diastolic diameter (LVEDD, ρ=−0.424, P=0.031). Moreover, multivariable regression analysis showed that the corrected calcium level was marginally associated with the LVEDD and corrected QT (QTc) interval (β=−0.366, P=0.068 and β=−0.252, P=0.070, respectively). CONCLUSION: Aldosterone-mediated hypercalciuria and subsequent hypocalcemia may be partly involved in the development of cardiac remodeling as well as a prolonged QTc interval, in subjects with PA, thereby triggering deleterious effects on target organs additively. Korean Endocrine Society 2018-12 2018-11-30 /pmc/articles/PMC6279903/ /pubmed/30513563 http://dx.doi.org/10.3803/EnM.2018.33.4.485 Text en Copyright © 2018 Korean Endocrine Society http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lim, Jung Soo Hong, Namki Park, Sungha Park, Sung Il Oh, Young Taik Yu, Min Heui Lim, Pil Yong Rhee, Yumie Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism |
title | Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism |
title_full | Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism |
title_fullStr | Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism |
title_full_unstemmed | Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism |
title_short | Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism |
title_sort | effects of altered calcium metabolism on cardiac parameters in primary aldosteronism |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279903/ https://www.ncbi.nlm.nih.gov/pubmed/30513563 http://dx.doi.org/10.3803/EnM.2018.33.4.485 |
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