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Non-coding RNAs Function as Immune Regulators in Teleost Fish

Non-coding RNAs (ncRNAs) are functional RNA molecules that are transcribed from DNA but not translated into proteins. ncRNAs function as key regulators of gene expression and chromatin modification. Recently, the functional role of ncRNAs in teleost fish has been extensively studied. Teleost fish ar...

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Detalles Bibliográficos
Autores principales: Wang, Man, Jiang, Shuai, Wu, Wei, Yu, Fei, Chang, Wenguang, Li, Peifeng, Wang, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279911/
https://www.ncbi.nlm.nih.gov/pubmed/30546368
http://dx.doi.org/10.3389/fimmu.2018.02801
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author Wang, Man
Jiang, Shuai
Wu, Wei
Yu, Fei
Chang, Wenguang
Li, Peifeng
Wang, Kun
author_facet Wang, Man
Jiang, Shuai
Wu, Wei
Yu, Fei
Chang, Wenguang
Li, Peifeng
Wang, Kun
author_sort Wang, Man
collection PubMed
description Non-coding RNAs (ncRNAs) are functional RNA molecules that are transcribed from DNA but not translated into proteins. ncRNAs function as key regulators of gene expression and chromatin modification. Recently, the functional role of ncRNAs in teleost fish has been extensively studied. Teleost fish are a highly diverse group among the vertebrate lineage. Fish are also important in terms of aquatic ecosystem, food production and human life, being the source of animal proteins worldwide and models of biomedical research. However, teleost fish always suffer from the invasion of infectious pathogens including viruses and bacteria, which has resulted in a tremendous economic loss to the fishing industry worldwide. Emerging evidence suggests that ncRNAs, especially miRNAs and lncRNAs, may serve as important regulators in cytokine and chemokine signaling, antigen presentation, complement and coagulation cascades, and T cell response in teleost fish. In this review, we summarize current knowledge and understanding of the roles of both miRNAs and lncRNAs in immune regulation in teleost fish. Molecular mechanism insights into the function of ncRNAs in fish immune response may contribute to the development of potential biomarkers and therapeutic targets for the prevention and treatment of fish diseases.
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spelling pubmed-62799112018-12-13 Non-coding RNAs Function as Immune Regulators in Teleost Fish Wang, Man Jiang, Shuai Wu, Wei Yu, Fei Chang, Wenguang Li, Peifeng Wang, Kun Front Immunol Immunology Non-coding RNAs (ncRNAs) are functional RNA molecules that are transcribed from DNA but not translated into proteins. ncRNAs function as key regulators of gene expression and chromatin modification. Recently, the functional role of ncRNAs in teleost fish has been extensively studied. Teleost fish are a highly diverse group among the vertebrate lineage. Fish are also important in terms of aquatic ecosystem, food production and human life, being the source of animal proteins worldwide and models of biomedical research. However, teleost fish always suffer from the invasion of infectious pathogens including viruses and bacteria, which has resulted in a tremendous economic loss to the fishing industry worldwide. Emerging evidence suggests that ncRNAs, especially miRNAs and lncRNAs, may serve as important regulators in cytokine and chemokine signaling, antigen presentation, complement and coagulation cascades, and T cell response in teleost fish. In this review, we summarize current knowledge and understanding of the roles of both miRNAs and lncRNAs in immune regulation in teleost fish. Molecular mechanism insights into the function of ncRNAs in fish immune response may contribute to the development of potential biomarkers and therapeutic targets for the prevention and treatment of fish diseases. Frontiers Media S.A. 2018-11-28 /pmc/articles/PMC6279911/ /pubmed/30546368 http://dx.doi.org/10.3389/fimmu.2018.02801 Text en Copyright © 2018 Wang, Jiang, Wu, Yu, Chang, Li and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Man
Jiang, Shuai
Wu, Wei
Yu, Fei
Chang, Wenguang
Li, Peifeng
Wang, Kun
Non-coding RNAs Function as Immune Regulators in Teleost Fish
title Non-coding RNAs Function as Immune Regulators in Teleost Fish
title_full Non-coding RNAs Function as Immune Regulators in Teleost Fish
title_fullStr Non-coding RNAs Function as Immune Regulators in Teleost Fish
title_full_unstemmed Non-coding RNAs Function as Immune Regulators in Teleost Fish
title_short Non-coding RNAs Function as Immune Regulators in Teleost Fish
title_sort non-coding rnas function as immune regulators in teleost fish
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279911/
https://www.ncbi.nlm.nih.gov/pubmed/30546368
http://dx.doi.org/10.3389/fimmu.2018.02801
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