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Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives

We had previously reported anticancer activity in the water extract (WEX) of Ashwagandha leaves, and identified Triethylene glycol (TEG) as an active tumor suppressor component. In this study, we investigated anti-migratory and anti-angiogenesis activities of WEX and TEG. We conducted in vitro and i...

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Autores principales: Oh, Eonju, Garg, Sukant, Liu, Ye, Afzal, Sajal, Gao, Ran, Yun, Chae-Ok, Kaul, Sunil C., Wadhwa, Renu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279921/
https://www.ncbi.nlm.nih.gov/pubmed/30547009
http://dx.doi.org/10.3389/fonc.2018.00552
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author Oh, Eonju
Garg, Sukant
Liu, Ye
Afzal, Sajal
Gao, Ran
Yun, Chae-Ok
Kaul, Sunil C.
Wadhwa, Renu
author_facet Oh, Eonju
Garg, Sukant
Liu, Ye
Afzal, Sajal
Gao, Ran
Yun, Chae-Ok
Kaul, Sunil C.
Wadhwa, Renu
author_sort Oh, Eonju
collection PubMed
description We had previously reported anticancer activity in the water extract (WEX) of Ashwagandha leaves, and identified Triethylene glycol (TEG) as an active tumor suppressor component. In this study, we investigated anti-migratory and anti-angiogenesis activities of WEX and TEG. We conducted in vitro and in vivo experiments using TEG, and its two derivatives, Triethyleneglycol dimethacrylate (TD-10), and Tetraethyleneglycol dimethacrylate (TD-11). The data revealed strong anticancer and anti-metastasis potentials in the derivatives. Non-toxic, anti-migratory doses of the derivatives showed inhibition of canonical Wnt/β-catenin axis and consequent downregulation of EMT-signaling proteins (Vimentin, MMPs and VEGF). These results endorse that the TD-10 and TD-11 have potential to safely put a check on the aggressiveness of the metastatic cells and therefore represent promising candidates for the treatment of metastatic cancers.
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spelling pubmed-62799212018-12-13 Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives Oh, Eonju Garg, Sukant Liu, Ye Afzal, Sajal Gao, Ran Yun, Chae-Ok Kaul, Sunil C. Wadhwa, Renu Front Oncol Oncology We had previously reported anticancer activity in the water extract (WEX) of Ashwagandha leaves, and identified Triethylene glycol (TEG) as an active tumor suppressor component. In this study, we investigated anti-migratory and anti-angiogenesis activities of WEX and TEG. We conducted in vitro and in vivo experiments using TEG, and its two derivatives, Triethyleneglycol dimethacrylate (TD-10), and Tetraethyleneglycol dimethacrylate (TD-11). The data revealed strong anticancer and anti-metastasis potentials in the derivatives. Non-toxic, anti-migratory doses of the derivatives showed inhibition of canonical Wnt/β-catenin axis and consequent downregulation of EMT-signaling proteins (Vimentin, MMPs and VEGF). These results endorse that the TD-10 and TD-11 have potential to safely put a check on the aggressiveness of the metastatic cells and therefore represent promising candidates for the treatment of metastatic cancers. Frontiers Media S.A. 2018-11-28 /pmc/articles/PMC6279921/ /pubmed/30547009 http://dx.doi.org/10.3389/fonc.2018.00552 Text en Copyright © 2018 Oh, Garg, Liu, Afzal, Gao, Yun, Kaul and Wadhwa. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Oh, Eonju
Garg, Sukant
Liu, Ye
Afzal, Sajal
Gao, Ran
Yun, Chae-Ok
Kaul, Sunil C.
Wadhwa, Renu
Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives
title Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives
title_full Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives
title_fullStr Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives
title_full_unstemmed Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives
title_short Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives
title_sort identification and functional characterization of anti-metastasis and anti-angiogenic activities of triethylene glycol derivatives
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279921/
https://www.ncbi.nlm.nih.gov/pubmed/30547009
http://dx.doi.org/10.3389/fonc.2018.00552
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