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Host Regulators of Liver Fibrosis During Human Schistosomiasis

Liver fibrosis is a wound-healing process purposely aimed at restoring organ integrity after severe injury caused by autoimmune reactions, mechanical stress or infections. The uncontrolled solicitation of this process is pathogenic and a pathognomonic feature of diseases like hepatosplenic schistoso...

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Autores principales: Kamdem, Severin Donald, Moyou-Somo, Roger, Brombacher, Frank, Nono, Justin Komguep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279936/
https://www.ncbi.nlm.nih.gov/pubmed/30546364
http://dx.doi.org/10.3389/fimmu.2018.02781
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author Kamdem, Severin Donald
Moyou-Somo, Roger
Brombacher, Frank
Nono, Justin Komguep
author_facet Kamdem, Severin Donald
Moyou-Somo, Roger
Brombacher, Frank
Nono, Justin Komguep
author_sort Kamdem, Severin Donald
collection PubMed
description Liver fibrosis is a wound-healing process purposely aimed at restoring organ integrity after severe injury caused by autoimmune reactions, mechanical stress or infections. The uncontrolled solicitation of this process is pathogenic and a pathognomonic feature of diseases like hepatosplenic schistosomiasis where exacerbated liver fibrosis is centrally positioned among the drivers of the disease morbidity and mortality. Intriguingly, however, liver fibrosis occurs and progresses dissimilarly in schistosomiasis-diseased individuals with the same egg burden and biosocial features including age, duration of residence in the endemic site and gender. This suggests that parasite-independent and currently poorly defined host intrinsic factors might play a defining role in the regulation of liver fibrosis, the hallmark of morbidity, during schistosomiasis. In this review, we therefore provide a comprehensive overview of all known host candidate regulators of liver fibrosis reported in the context of human schistosomiasis.
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spelling pubmed-62799362018-12-13 Host Regulators of Liver Fibrosis During Human Schistosomiasis Kamdem, Severin Donald Moyou-Somo, Roger Brombacher, Frank Nono, Justin Komguep Front Immunol Immunology Liver fibrosis is a wound-healing process purposely aimed at restoring organ integrity after severe injury caused by autoimmune reactions, mechanical stress or infections. The uncontrolled solicitation of this process is pathogenic and a pathognomonic feature of diseases like hepatosplenic schistosomiasis where exacerbated liver fibrosis is centrally positioned among the drivers of the disease morbidity and mortality. Intriguingly, however, liver fibrosis occurs and progresses dissimilarly in schistosomiasis-diseased individuals with the same egg burden and biosocial features including age, duration of residence in the endemic site and gender. This suggests that parasite-independent and currently poorly defined host intrinsic factors might play a defining role in the regulation of liver fibrosis, the hallmark of morbidity, during schistosomiasis. In this review, we therefore provide a comprehensive overview of all known host candidate regulators of liver fibrosis reported in the context of human schistosomiasis. Frontiers Media S.A. 2018-11-28 /pmc/articles/PMC6279936/ /pubmed/30546364 http://dx.doi.org/10.3389/fimmu.2018.02781 Text en Copyright © 2018 Kamdem, Moyou-Somo, Brombacher and Nono. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kamdem, Severin Donald
Moyou-Somo, Roger
Brombacher, Frank
Nono, Justin Komguep
Host Regulators of Liver Fibrosis During Human Schistosomiasis
title Host Regulators of Liver Fibrosis During Human Schistosomiasis
title_full Host Regulators of Liver Fibrosis During Human Schistosomiasis
title_fullStr Host Regulators of Liver Fibrosis During Human Schistosomiasis
title_full_unstemmed Host Regulators of Liver Fibrosis During Human Schistosomiasis
title_short Host Regulators of Liver Fibrosis During Human Schistosomiasis
title_sort host regulators of liver fibrosis during human schistosomiasis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279936/
https://www.ncbi.nlm.nih.gov/pubmed/30546364
http://dx.doi.org/10.3389/fimmu.2018.02781
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