Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency

Mitochondrial NADP(+)-dependent isocitrate dehydrogenase 2 (IDH2) is a major NADPH-producing enzyme which is essential for maintaining the mitochondrial redox balance in cells. We sought to determine whether IDH2 deficiency induces mitochondrial dysfunction and modulates auditory function, and inves...

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Detalles Bibliográficos
Autores principales: Kim, Ye-Ri, Baek, Jeong-In, Kim, Sung Hwan, Kim, Min-A, Lee, Byeonghyeon, Ryu, Nari, Kim, Kyung-Hee, Choi, Deok-Gyun, Kim, Hye-Min, Murphy, Michael P., Macpherson, Greg, Choo, Yeon-Sik, Bok, Jinwoong, Lee, Kyu-Yup, Park, Jeen-Woo, Kim, Un-Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279977/
https://www.ncbi.nlm.nih.gov/pubmed/30508699
http://dx.doi.org/10.1016/j.redox.2018.11.013

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