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Case Report: presentation of pleomorphic liposarcoma arising in a borderline phyllodes tumor
INTRODUCTION: The stromal component of Phyllodes tumors represents the neoplastic portion of the lesion. A variety of associated malignancies can arise from PTs, with its dual population of cells. PRESENTATION OF CASE: We share a very rare case of “borderline”breast phillodes tumour with a 75% lipos...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280005/ https://www.ncbi.nlm.nih.gov/pubmed/30567077 http://dx.doi.org/10.1016/j.ijscr.2018.10.038 |
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author | Polat, Yalçın Arslan, Gözde Kebudi, Abud Apa, Duygu Düşmez |
author_facet | Polat, Yalçın Arslan, Gözde Kebudi, Abud Apa, Duygu Düşmez |
author_sort | Polat, Yalçın |
collection | PubMed |
description | INTRODUCTION: The stromal component of Phyllodes tumors represents the neoplastic portion of the lesion. A variety of associated malignancies can arise from PTs, with its dual population of cells. PRESENTATION OF CASE: We share a very rare case of “borderline”breast phillodes tumour with a 75% liposarcoma component. A 48-year-old woman presented at the surgical clinic with a mass in the left breast. On mammograms, the lesion was dense with radiolucent areas inside which were thought to be compatible with fat. The mass was assumed to be breast imaging-reporting and data system (BIRADS) 3 on sonography as it was well contoured. The needle biopsy was reported to be consistent with a fibroadenomatous lesion. The lesion was completely excised. On microscopic examination, the lesion has benign mammary duct epithelium lining the slit-like spaces. The stroma composed of fibrous and adipous tissue. The fibrous part was cellular, and several cells appeared bizarre. Adipous tissue replaced most of the stroma and was diagnosed as pleomorphic liposarcoma. DISCUSSION: According to the 3 tiered grading criteria of PTs, our case normally suits in borderline category, without liposarcoma component. Heterologous sarcomatous elements usually accompany high grade PTs. Rare cases of benign and borderline PTs with sarcoma component have been reported. CONCLUSION: The presence of a malignant heterologous component places the tumour into the malignant category regardless of other histological features. |
format | Online Article Text |
id | pubmed-6280005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-62800052019-02-13 Case Report: presentation of pleomorphic liposarcoma arising in a borderline phyllodes tumor Polat, Yalçın Arslan, Gözde Kebudi, Abud Apa, Duygu Düşmez Int J Surg Case Rep Article INTRODUCTION: The stromal component of Phyllodes tumors represents the neoplastic portion of the lesion. A variety of associated malignancies can arise from PTs, with its dual population of cells. PRESENTATION OF CASE: We share a very rare case of “borderline”breast phillodes tumour with a 75% liposarcoma component. A 48-year-old woman presented at the surgical clinic with a mass in the left breast. On mammograms, the lesion was dense with radiolucent areas inside which were thought to be compatible with fat. The mass was assumed to be breast imaging-reporting and data system (BIRADS) 3 on sonography as it was well contoured. The needle biopsy was reported to be consistent with a fibroadenomatous lesion. The lesion was completely excised. On microscopic examination, the lesion has benign mammary duct epithelium lining the slit-like spaces. The stroma composed of fibrous and adipous tissue. The fibrous part was cellular, and several cells appeared bizarre. Adipous tissue replaced most of the stroma and was diagnosed as pleomorphic liposarcoma. DISCUSSION: According to the 3 tiered grading criteria of PTs, our case normally suits in borderline category, without liposarcoma component. Heterologous sarcomatous elements usually accompany high grade PTs. Rare cases of benign and borderline PTs with sarcoma component have been reported. CONCLUSION: The presence of a malignant heterologous component places the tumour into the malignant category regardless of other histological features. Elsevier 2018-11-01 /pmc/articles/PMC6280005/ /pubmed/30567077 http://dx.doi.org/10.1016/j.ijscr.2018.10.038 Text en © 2018 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Polat, Yalçın Arslan, Gözde Kebudi, Abud Apa, Duygu Düşmez Case Report: presentation of pleomorphic liposarcoma arising in a borderline phyllodes tumor |
title | Case Report: presentation of pleomorphic liposarcoma arising in a borderline phyllodes tumor |
title_full | Case Report: presentation of pleomorphic liposarcoma arising in a borderline phyllodes tumor |
title_fullStr | Case Report: presentation of pleomorphic liposarcoma arising in a borderline phyllodes tumor |
title_full_unstemmed | Case Report: presentation of pleomorphic liposarcoma arising in a borderline phyllodes tumor |
title_short | Case Report: presentation of pleomorphic liposarcoma arising in a borderline phyllodes tumor |
title_sort | case report: presentation of pleomorphic liposarcoma arising in a borderline phyllodes tumor |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280005/ https://www.ncbi.nlm.nih.gov/pubmed/30567077 http://dx.doi.org/10.1016/j.ijscr.2018.10.038 |
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