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A Cell Atlas for the Mouse Brain
Despite vast numbers of studies of stained cells in the mouse brain, no current brain atlas provides region-by-region neuron counts. In fact, neuron numbers are only available for about 4% of brain of regions and estimates often vary by as much as 3-fold. Here we provide a first 3D cell atlas for th...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280067/ https://www.ncbi.nlm.nih.gov/pubmed/30546301 http://dx.doi.org/10.3389/fninf.2018.00084 |
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author | Erö, Csaba Gewaltig, Marc-Oliver Keller, Daniel Markram, Henry |
author_facet | Erö, Csaba Gewaltig, Marc-Oliver Keller, Daniel Markram, Henry |
author_sort | Erö, Csaba |
collection | PubMed |
description | Despite vast numbers of studies of stained cells in the mouse brain, no current brain atlas provides region-by-region neuron counts. In fact, neuron numbers are only available for about 4% of brain of regions and estimates often vary by as much as 3-fold. Here we provide a first 3D cell atlas for the whole mouse brain, showing cell positions constructed algorithmically from whole brain Nissl and gene expression stains, and compared against values from the literature. The atlas provides the densities and positions of all excitatory and inhibitory neurons, astrocytes, oligodendrocytes, and microglia in each of the 737 brain regions defined in the AMBA. The atlas is dynamic, allowing comparison with previously reported numbers, addition of cell types, and improvement of estimates as new data is integrated. The atlas also provides insights into cellular organization only possible at this whole brain scale, and is publicly available. |
format | Online Article Text |
id | pubmed-6280067 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62800672018-12-13 A Cell Atlas for the Mouse Brain Erö, Csaba Gewaltig, Marc-Oliver Keller, Daniel Markram, Henry Front Neuroinform Neuroscience Despite vast numbers of studies of stained cells in the mouse brain, no current brain atlas provides region-by-region neuron counts. In fact, neuron numbers are only available for about 4% of brain of regions and estimates often vary by as much as 3-fold. Here we provide a first 3D cell atlas for the whole mouse brain, showing cell positions constructed algorithmically from whole brain Nissl and gene expression stains, and compared against values from the literature. The atlas provides the densities and positions of all excitatory and inhibitory neurons, astrocytes, oligodendrocytes, and microglia in each of the 737 brain regions defined in the AMBA. The atlas is dynamic, allowing comparison with previously reported numbers, addition of cell types, and improvement of estimates as new data is integrated. The atlas also provides insights into cellular organization only possible at this whole brain scale, and is publicly available. Frontiers Media S.A. 2018-11-28 /pmc/articles/PMC6280067/ /pubmed/30546301 http://dx.doi.org/10.3389/fninf.2018.00084 Text en Copyright © 2018 Erö, Gewaltig, Keller and Markram. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Erö, Csaba Gewaltig, Marc-Oliver Keller, Daniel Markram, Henry A Cell Atlas for the Mouse Brain |
title | A Cell Atlas for the Mouse Brain |
title_full | A Cell Atlas for the Mouse Brain |
title_fullStr | A Cell Atlas for the Mouse Brain |
title_full_unstemmed | A Cell Atlas for the Mouse Brain |
title_short | A Cell Atlas for the Mouse Brain |
title_sort | cell atlas for the mouse brain |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280067/ https://www.ncbi.nlm.nih.gov/pubmed/30546301 http://dx.doi.org/10.3389/fninf.2018.00084 |
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