Attempted use of PACE for riboswitch discovery generates three new translational theophylline riboswitch side products

OBJECTIVE: The purpose of this project was to use an in vivo method to discover riboswitches that are activated by new ligands. We employed phage-assisted continuous evolution (PACE) to evolve new riboswitches in vivo. We started with one translational riboswitch and one transcriptional riboswitch,...

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Detalles Bibliográficos
Autores principales: Shaver, Zachary M., Bent, Stephanie S., Bilby, Steven R., Brown, Michael, Buser, Anna, Cuellar, Itzayana G., Davis, Athena J., Doolan, Lindsay, Enriquez, Fatima C., Estrada, Autumn, Herner, Shelby, Herron, J. Cody, Hunn, Andrew M., Hunter, Madison, Johnston, Hartlee, Koucky, Owen, Mackley, Christian C., Maghini, Dylan, Mattoon, Devin, McDonald, Haden T., Sinks, Hannah, Sprague, Austin J., Sullivan, David, Tutar, Altan, Umphreys, Avery, Watson, Chris, Zweerink, Daniel, Heyer, Laurie J., Poet, Jeffrey L., Eckdahl, Todd T., Campbell, A. Malcolm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280357/
https://www.ncbi.nlm.nih.gov/pubmed/30518404
http://dx.doi.org/10.1186/s13104-018-3965-6

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