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Prognostic role of myeloid-derived suppressor cells in cancers: a systematic review and meta-analysis

BACKGROUND: Myeloid-derived suppressor cells (MDSCs) is a heterogeneous population of immature myeloid cells, inhibiting both the innate and adaptive immunity. Recent studies validated that MDSCs caused immune suppression and promoted cancer progression through various mechanisms. However, the progn...

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Autores principales: Ai, Lisha, Mu, Shidai, Wang, Yadan, Wang, Huafang, Cai, Li, Li, Wenzhu, Hu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280417/
https://www.ncbi.nlm.nih.gov/pubmed/30518340
http://dx.doi.org/10.1186/s12885-018-5086-y
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author Ai, Lisha
Mu, Shidai
Wang, Yadan
Wang, Huafang
Cai, Li
Li, Wenzhu
Hu, Yu
author_facet Ai, Lisha
Mu, Shidai
Wang, Yadan
Wang, Huafang
Cai, Li
Li, Wenzhu
Hu, Yu
author_sort Ai, Lisha
collection PubMed
description BACKGROUND: Myeloid-derived suppressor cells (MDSCs) is a heterogeneous population of immature myeloid cells, inhibiting both the innate and adaptive immunity. Recent studies validated that MDSCs caused immune suppression and promoted cancer progression through various mechanisms. However, the prognostic value of MDSCs in cancer remains controversial. METHODS: Here, we performed this meta-analysis to evaluate the prognostic value of MDSCs in various types of cancer. The electric databases, such as Pubmed, Embase and Web of Science, were searched for relevant publications. Hazards ratios (HRs) with the corresponding 95% confidence intervals (95%CIs) were calculated to evaluate the prognostic role of MDSCs in cancer. RESULTS: A total of 16 studies with 1864 patients were enrolled in our meta-analysis. Elevated MDSCs frequency was shown to be associated with shorter overall survival (OS) (HR = 2.46, 95%CI: 1.87–3.23), and poor disease-free survival / recurrence-free survival (DFS / RFS) (HR = 3.26, 95%CI: 2.10–5.04) after treatment. Furthermore, similar results were also observed in the stratified subgroup analysis, which included the analysis by region, sample size, cancer type, NOS scores, subtype and cut-off value of MDSCs. CONCLUSION: High MDSCs might be related to poor clinical outcomes of patients with cancer, that is, MDSCs might be a potential prognostic biomarker in cancer.
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spelling pubmed-62804172018-12-10 Prognostic role of myeloid-derived suppressor cells in cancers: a systematic review and meta-analysis Ai, Lisha Mu, Shidai Wang, Yadan Wang, Huafang Cai, Li Li, Wenzhu Hu, Yu BMC Cancer Research Article BACKGROUND: Myeloid-derived suppressor cells (MDSCs) is a heterogeneous population of immature myeloid cells, inhibiting both the innate and adaptive immunity. Recent studies validated that MDSCs caused immune suppression and promoted cancer progression through various mechanisms. However, the prognostic value of MDSCs in cancer remains controversial. METHODS: Here, we performed this meta-analysis to evaluate the prognostic value of MDSCs in various types of cancer. The electric databases, such as Pubmed, Embase and Web of Science, were searched for relevant publications. Hazards ratios (HRs) with the corresponding 95% confidence intervals (95%CIs) were calculated to evaluate the prognostic role of MDSCs in cancer. RESULTS: A total of 16 studies with 1864 patients were enrolled in our meta-analysis. Elevated MDSCs frequency was shown to be associated with shorter overall survival (OS) (HR = 2.46, 95%CI: 1.87–3.23), and poor disease-free survival / recurrence-free survival (DFS / RFS) (HR = 3.26, 95%CI: 2.10–5.04) after treatment. Furthermore, similar results were also observed in the stratified subgroup analysis, which included the analysis by region, sample size, cancer type, NOS scores, subtype and cut-off value of MDSCs. CONCLUSION: High MDSCs might be related to poor clinical outcomes of patients with cancer, that is, MDSCs might be a potential prognostic biomarker in cancer. BioMed Central 2018-12-05 /pmc/articles/PMC6280417/ /pubmed/30518340 http://dx.doi.org/10.1186/s12885-018-5086-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ai, Lisha
Mu, Shidai
Wang, Yadan
Wang, Huafang
Cai, Li
Li, Wenzhu
Hu, Yu
Prognostic role of myeloid-derived suppressor cells in cancers: a systematic review and meta-analysis
title Prognostic role of myeloid-derived suppressor cells in cancers: a systematic review and meta-analysis
title_full Prognostic role of myeloid-derived suppressor cells in cancers: a systematic review and meta-analysis
title_fullStr Prognostic role of myeloid-derived suppressor cells in cancers: a systematic review and meta-analysis
title_full_unstemmed Prognostic role of myeloid-derived suppressor cells in cancers: a systematic review and meta-analysis
title_short Prognostic role of myeloid-derived suppressor cells in cancers: a systematic review and meta-analysis
title_sort prognostic role of myeloid-derived suppressor cells in cancers: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280417/
https://www.ncbi.nlm.nih.gov/pubmed/30518340
http://dx.doi.org/10.1186/s12885-018-5086-y
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