Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes

Mosaic mutations present in the germline have important implications for reproductive risk and disease transmission. We previously demonstrated a phenomenon occurring in the male germline, whereby specific mutations arising spontaneously in stem cells (spermatogonia) lead to clonal expansion, result...

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Detalles Bibliográficos
Autores principales: Maher, Geoffrey J., Ralph, Hannah K., Ding, Zhihao, Koelling, Nils, Mlcochova, Hana, Giannoulatou, Eleni, Dhami, Pawan, Paul, Dirk S., Stricker, Stefan H., Beck, Stephan, McVean, Gilean, Wilkie, Andrew O.M., Goriely, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280762/
https://www.ncbi.nlm.nih.gov/pubmed/30355600
http://dx.doi.org/10.1101/gr.239186.118

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