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Crystal structure and Hirshfeld surface analysis of two imidazo[1,2-a]pyridine derivatives: N-tert-butyl-2-(4-meth­oxy­phen­yl)-5-methyl­imidazo[1,2-a]pyridin-3-amine and N-tert-butyl-2-[4-(di­methyl­amino)­phen­yl]imidazo[1,2-a]pyridin-3-amine

In the title imidazo[1,2-a]pyridine derivatives, N-tert-butyl-2-(4-meth­oxy­phen­yl)-5-methyl­imidazo[1,2-a]pyridin-3-amine, C(19)H(23)N(3)O, (I), and N-tert-butyl-2-[4-(di­methyl­amino)­phen­yl]imidazo[1,2-a]pyridin-3-amine, C(19)H(24)N(4), (II), the 4-meth­oxy­phenyl ring in (I) and the 4-(di­meth...

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Detalles Bibliográficos
Autores principales: Dhanalakshmi, G., Ramanjaneyulu, Mala, Thennarasu, Sathiah, Aravindhan, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281107/
https://www.ncbi.nlm.nih.gov/pubmed/30574400
http://dx.doi.org/10.1107/S2056989018016651
Descripción
Sumario:In the title imidazo[1,2-a]pyridine derivatives, N-tert-butyl-2-(4-meth­oxy­phen­yl)-5-methyl­imidazo[1,2-a]pyridin-3-amine, C(19)H(23)N(3)O, (I), and N-tert-butyl-2-[4-(di­methyl­amino)­phen­yl]imidazo[1,2-a]pyridin-3-amine, C(19)H(24)N(4), (II), the 4-meth­oxy­phenyl ring in (I) and the 4-(di­methyl­amino)­phenyl ring in (II) are inclined to the respective imidazole rings by 26.69 (9) and 31.35 (10)°. In the crystal of (I), mol­ecules are linked by N—H⋯N hydrogen bonds, forming chains propagating along the [001] direction. The chains are linked by C—H⋯π inter­actions, forming layers parallel to the (010) plane. In (II), the crystal packing also features N—H⋯N hydrogen bonds, which together with C—H⋯N hydrogen bonds link mol­ecules to form chains propagating along the c-axis direction. The chains are linked by C—H⋯π inter­actions to form layers parallel to the (100) plane. Inversion-related layers are linked by offset π–π inter­actions [inter­centroid distance = 3.577 (1) Å]. The inter­molecular inter­actions of both compounds were analyzed using Hirshfeld surface analysis and two-dimensional fingerprint plots.