Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations

The ApoE ε4 allele is the most significant genetic risk factor for late-onset Alzheimer disease. The risk conferred by ε4, however, differs across populations, with populations of African ancestry showing lower ε4 risk compared to those of European or Asian ancestry. The cause of this heterogeneity...

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Detalles Bibliográficos
Autores principales: Rajabli, Farid, Feliciano, Briseida E., Celis, Katrina, Hamilton-Nelson, Kara L., Whitehead, Patrice L., Adams, Larry D., Bussies, Parker L., Manrique, Clara P., Rodriguez, Alejandra, Rodriguez, Vanessa, Starks, Takiyah, Byfield, Grace E., Sierra Lopez, Carolina B., McCauley, Jacob L., Acosta, Heriberto, Chinea, Angel, Kunkle, Brian W., Reitz, Christiane, Farrer, Lindsay A., Schellenberg, Gerard D., Vardarajan, Badri N., Vance, Jeffery M., Cuccaro, Michael L., Martin, Eden R., Haines, Jonathan L., Byrd, Goldie S., Beecham, Gary W., Pericak-Vance, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281216/
https://www.ncbi.nlm.nih.gov/pubmed/30517106
http://dx.doi.org/10.1371/journal.pgen.1007791

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