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Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity
Dietary, pharmacological and genetic interventions can extend health- and lifespan in diverse mammalian species. DNA methylation has been implicated in mediating the beneficial effects of these interventions; methylation patterns deteriorate during ageing, and this is prevented by lifespan-extending...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281273/ https://www.ncbi.nlm.nih.gov/pubmed/30462643 http://dx.doi.org/10.1371/journal.pgen.1007766 |