Cargando…

Glucose intake hampers PKA-regulated HSP90 chaperone activity

Aging is an intricate phenomenon associated with the gradual loss of physiological functions, and both nutrient sensing and proteostasis control lifespan. Although multiple approaches have facilitated the identification of candidate genes that govern longevity, the molecular mechanisms that link agi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yu-Chen, Jiang, Pei-Heng, Chen, Hsuan-Ming, Chen, Chang-Han, Wang, Yi-Ting, Chen, Yu-Ju, Yu, Chia-Jung, Teng, Shu-Chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281317/ https://www.ncbi.nlm.nih.gov/pubmed/30516470 http://dx.doi.org/10.7554/eLife.39925

Ejemplares similares

NudC L279P Mutation Destabilizes Filamin A by Inhibiting the Hsp90 Chaperoning Pathway and Suppresses Cell Migration
por: Liu, Min, et al.
Publicado: (2021)

Molecular Chaperone Hsp90 Is a Therapeutic Target for Noroviruses
por: Vashist, Surender, et al.
Publicado: (2015)

Corrigendum: NudC L279P mutation destabilizes filamin a by inhibiting the Hsp90 chaperoning pathway and suppresses cell migration
por: Liu, Min, et al.
Publicado: (2023)

Hsp90 Chaperones Bluetongue Virus Proteins and Prevents Proteasomal Degradation
por: Mohl, Bjorn-Patrick, et al.
Publicado: (2019)

Distinct Roles of Molecular Chaperones HSP90α and HSP90β in the Biogenesis of KCNQ4 Channels
por: Gao, Yanhong, et al.
Publicado: (2013)

Quantitative analysis of the interplay between hsc70 and its co-chaperone HspBP1
por: Mahboubi, Hicham, et al.
Publicado: (2015)

Hsp110 Chaperones Control Client Fate Determination in the Hsp70–Hsp90 Chaperone System
por: Mandal, Atin K., et al.
Publicado: (2010)

Cytosolic Hsp70 and co-chaperones constitute a novel system for tRNA import into the nucleus
por: Takano, Akira, et al.
Publicado: (2015)

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases
por: Lackie, Rachel E., et al.
Publicado: (2017)

A Cytosolic Relay of Heat Shock Proteins HSP70-1A and HSP90β Monitors the Folding Trajectory of the Serotonin Transporter
por: El-Kasaby, Ali, et al.
Publicado: (2014)

Hsp90 (Heat Shock Protein 90) Inhibitor Occupancy Is a Direct Determinant of Client Protein Degradation and Tumor Growth Arrest in Vivo
por: Tillotson, Bonnie, et al.
Publicado: (2010)

The chaperone system in cancer therapies: Hsp90
por: Basset, Charbel A., et al.
Publicado: (2023)

An HSP90 cochaperone Ids2 maintains the stability of mitochondrial DNA and ATP synthase
por: Jiang, Pei-Heng, et al.
Publicado: (2021)

Uncoupling the Hsp90 and DnaK chaperone activities revealed the in vivo relevance of their collaboration in bacteria
por: Corteggiani, Marie, et al.
Publicado: (2022)

Alterations of the Hsp70/Hsp90 chaperone and the HOP/CHIP co-chaperone system in cancer
por: Ruckova, Eva, et al.
Publicado: (2012)

HSP90 Inhibitor 17-AAG Attenuates Nucleus Pulposus Inflammation and Catabolism Induced by M1-Polarized Macrophages
por: Zhang, Shuo, et al.
Publicado: (2022)

The Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90
por: Alberti, Giusi, et al.
Publicado: (2022)

Hsp40s Specify Functions of Hsp104 and Hsp90 Protein Chaperone Machines
por: Reidy, Michael, et al.
Publicado: (2014)

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies
por: Shelton, Lindsey B., et al.
Publicado: (2017)

Review: The HSP90 molecular chaperone—an enigmatic ATPase
por: Pearl, Laurence H.
Publicado: (2016)

Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases
por: Bohush, Anastasiia, et al.
Publicado: (2019)

Hsp90 and Associated Co-Chaperones of the Malaria Parasite
por: Dutta, Tanima, et al.
Publicado: (2022)

Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery
por: Li, Ting, et al.
Publicado: (2018)

Extracellular HSP90 Machineries Build Tumor Microenvironment and Boost Cancer Progression
por: Poggio, Pietro, et al.
Publicado: (2021)

Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy
por: Shen, Shensi, et al.
Publicado: (2009)

Necdin regulates BMAL1 stability and circadian clock through SGT1-HSP90 chaperone machinery
por: Lu, Renbin, et al.
Publicado: (2020)

Loss of Function of mtHsp70 Chaperone Variants Leads to Mitochondrial Dysfunction in Congenital Sideroblastic Anemia
por: Vishwanathan, Vinaya, et al.
Publicado: (2022)

Hsp90 S-nitrosylation at Cys521, as a conformational switch, modulates cycling of Hsp90-AHA1-CDC37 chaperone machine to aggravate atherosclerosis
por: Zhao, Shuang, et al.
Publicado: (2022)

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding
por: Woodford, Mark R., et al.
Publicado: (2016)

HSP70 and HSP90 in Cancer: Cytosolic, Endoplasmic Reticulum and Mitochondrial Chaperones of Tumorigenesis
por: Albakova, Zarema, et al.
Publicado: (2022)

Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease
por: Rutledge, Benjamin S., et al.
Publicado: (2022)

Tamoxifen Enhances the Hsp90 Molecular Chaperone ATPase Activity
por: Zhao, Rongmin, et al.
Publicado: (2010)

Extended conformational states dominate the Hsp90 chaperone dynamics
por: Jussupow, Alexander, et al.
Publicado: (2022)

Plasma HSP90AA1 Predicts the Risk of Breast Cancer Onset and Distant Metastasis
por: Liu, Haizhou, et al.
Publicado: (2021)

Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion
por: Lekszas, Caroline, et al.
Publicado: (2020)

Inhibition of PFKFB3 Hampers the Progression of Atherosclerosis and Promotes Plaque Stability
por: Poels, Kikkie, et al.
Publicado: (2020)

Allosteric Regulation of Hsp90α’s Activity by Small Molecules Targeting the Middle Domain of the Chaperone
por: Zhou, Chen, et al.
Publicado: (2020)

Silencing VEGFR-2 Hampers Odontoblastic Differentiation of Dental Pulp Stem Cells
por: Janebodin, Kajohnkiart, et al.
Publicado: (2021)

Corrigendum: HSP70 and HSP90 in cancer: cytosolic, endoplasmic reticulum and mitochondrial chaperones of tumorigenesis
por: Albakova, Zarema, et al.
Publicado: (2023)

Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors
por: Gillis, Joanna L., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_t9knb792c5bockrauqc9n2sdhi