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Corollary discharge in precerebellar nuclei of sleeping infant rats

In week-old rats, somatosensory input arises predominantly from external stimuli or from sensory feedback (reafference) associated with myoclonic twitches during active sleep. A previous study suggested that the brainstem motor structures that produce twitches also send motor copies (or corollary di...

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Detalles Bibliográficos
Autores principales: Mukherjee, Didhiti, Sokoloff, Greta, Blumberg, Mark S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281370/
https://www.ncbi.nlm.nih.gov/pubmed/30516134
http://dx.doi.org/10.7554/eLife.38213
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author Mukherjee, Didhiti
Sokoloff, Greta
Blumberg, Mark S
author_facet Mukherjee, Didhiti
Sokoloff, Greta
Blumberg, Mark S
author_sort Mukherjee, Didhiti
collection PubMed
description In week-old rats, somatosensory input arises predominantly from external stimuli or from sensory feedback (reafference) associated with myoclonic twitches during active sleep. A previous study suggested that the brainstem motor structures that produce twitches also send motor copies (or corollary discharge, CD) to the cerebellum. We tested this possibility by recording from two precerebellar nuclei—the inferior olive (IO) and lateral reticular nucleus (LRN). In most IO and LRN neurons, twitch-related activity peaked sharply around twitch onset, consistent with CD. Next, we identified twitch-production areas in the midbrain that project independently to the IO and LRN. Finally, we blocked calcium-activated slow potassium (SK) channels in the IO to explain how broadly tuned brainstem motor signals can be transformed into precise CD signals. We conclude that the precerebellar nuclei convey a diversity of sleep-related neural activity to the developing cerebellum to enable processing of convergent input from CD and reafferent signals.
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spelling pubmed-62813702018-12-07 Corollary discharge in precerebellar nuclei of sleeping infant rats Mukherjee, Didhiti Sokoloff, Greta Blumberg, Mark S eLife Neuroscience In week-old rats, somatosensory input arises predominantly from external stimuli or from sensory feedback (reafference) associated with myoclonic twitches during active sleep. A previous study suggested that the brainstem motor structures that produce twitches also send motor copies (or corollary discharge, CD) to the cerebellum. We tested this possibility by recording from two precerebellar nuclei—the inferior olive (IO) and lateral reticular nucleus (LRN). In most IO and LRN neurons, twitch-related activity peaked sharply around twitch onset, consistent with CD. Next, we identified twitch-production areas in the midbrain that project independently to the IO and LRN. Finally, we blocked calcium-activated slow potassium (SK) channels in the IO to explain how broadly tuned brainstem motor signals can be transformed into precise CD signals. We conclude that the precerebellar nuclei convey a diversity of sleep-related neural activity to the developing cerebellum to enable processing of convergent input from CD and reafferent signals. eLife Sciences Publications, Ltd 2018-12-05 /pmc/articles/PMC6281370/ /pubmed/30516134 http://dx.doi.org/10.7554/eLife.38213 Text en © 2018, Mukherjee et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Mukherjee, Didhiti
Sokoloff, Greta
Blumberg, Mark S
Corollary discharge in precerebellar nuclei of sleeping infant rats
title Corollary discharge in precerebellar nuclei of sleeping infant rats
title_full Corollary discharge in precerebellar nuclei of sleeping infant rats
title_fullStr Corollary discharge in precerebellar nuclei of sleeping infant rats
title_full_unstemmed Corollary discharge in precerebellar nuclei of sleeping infant rats
title_short Corollary discharge in precerebellar nuclei of sleeping infant rats
title_sort corollary discharge in precerebellar nuclei of sleeping infant rats
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281370/
https://www.ncbi.nlm.nih.gov/pubmed/30516134
http://dx.doi.org/10.7554/eLife.38213
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