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Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro

We previously demonstrated that an integrated XIST transgene can broadly repress one chromosome 21 in Down syndrome (DS) pluripotent cells. Here we address whether trisomy-silencing can normalize cell function and development sufficiently to correct cell pathogenesis, tested in an in vitro model of...

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Detalles Bibliográficos
Autores principales:	Chiang, Jen-Chieh, Jiang, Jun, Newburger, Peter E., Lawrence, Jeanne B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281598/ https://www.ncbi.nlm.nih.gov/pubmed/30518921 http://dx.doi.org/10.1038/s41467-018-07630-y

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