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NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway
NLRP3 is a cytosolic sensor triggered by different pathogen- and self-derived signals that plays a central role in a variety of pathological conditions, including sterile inflammation. The leucine-rich repeat domain is present in several innate immune receptors, where it is frequently responsible fo...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281599/ https://www.ncbi.nlm.nih.gov/pubmed/30518920 http://dx.doi.org/10.1038/s41467-018-07573-4 |