Induction of immunosuppressive functions and NF-κB by FLIP in monocytes

Immunosuppression is a hallmark of tumor progression, and treatments that inhibit or deplete monocytic myeloid-derived suppressive cells could promote anti-tumor immunity. c-FLIP is a central regulator of caspase-8-mediated apoptosis and necroptosis. Here we show that low-dose cytotoxic chemotherapy...

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Detalles Bibliográficos
Autores principales: Fiore, Alessandra, Ugel, Stefano, De Sanctis, Francesco, Sandri, Sara, Fracasso, Giulio, Trovato, Rosalinda, Sartoris, Silvia, Solito, Samantha, Mandruzzato, Susanna, Vascotto, Fulvia, Hippen, Keli L., Mondanelli, Giada, Grohmann, Ursula, Piro, Geny, Carbone, Carmine, Melisi, Davide, Lawlor, Rita T., Scarpa, Aldo, Lamolinara, Alessia, Iezzi, Manuela, Fassan, Matteo, Bicciato, Silvio, Blazar, Bruce R., Sahin, Ugur, Murray, Peter J., Bronte, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281604/
https://www.ncbi.nlm.nih.gov/pubmed/30518925
http://dx.doi.org/10.1038/s41467-018-07654-4

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