A downy mildew effector evades recognition by polymorphism of expression and subcellular localization

Pathogen co-evolution with plants involves selection for evasion of host surveillance systems. The oomycete Hyaloperonospora arabidopsidis (Hpa) causes downy mildew on Arabidopsis, and race-specific interactions between Arabidopsis accessions and Hpa isolates fit the gene-for-gene model in which hos...

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Autores principales: Asai, Shuta, Furzer, Oliver J., Cevik, Volkan, Kim, Dae Sung, Ishaque, Naveed, Goritschnig, Sandra, Staskawicz, Brian J., Shirasu, Ken, Jones, Jonathan D. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281644/
https://www.ncbi.nlm.nih.gov/pubmed/30518923
http://dx.doi.org/10.1038/s41467-018-07469-3
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author Asai, Shuta
Furzer, Oliver J.
Cevik, Volkan
Kim, Dae Sung
Ishaque, Naveed
Goritschnig, Sandra
Staskawicz, Brian J.
Shirasu, Ken
Jones, Jonathan D. G.
author_facet Asai, Shuta
Furzer, Oliver J.
Cevik, Volkan
Kim, Dae Sung
Ishaque, Naveed
Goritschnig, Sandra
Staskawicz, Brian J.
Shirasu, Ken
Jones, Jonathan D. G.
author_sort Asai, Shuta
collection PubMed
description Pathogen co-evolution with plants involves selection for evasion of host surveillance systems. The oomycete Hyaloperonospora arabidopsidis (Hpa) causes downy mildew on Arabidopsis, and race-specific interactions between Arabidopsis accessions and Hpa isolates fit the gene-for-gene model in which host resistance or susceptibility are determined by matching pairs of plant Resistance (R) genes and pathogen Avirulence (AVR) genes. Arabidopsis Col-0 carries R gene RPP4 that confers resistance to Hpa isolates Emoy2 and Emwa1, but its cognate recognized effector(s) were unknown. We report here the identification of the Emoy2 AVR effector gene recognized by RPP4 and show resistance-breaking isolates of Hpa on RPP4-containing Arabidopsis carry the alleles that either are not expressed, or show cytoplasmic instead of nuclear subcellular localization.
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spelling pubmed-62816442018-12-07 A downy mildew effector evades recognition by polymorphism of expression and subcellular localization Asai, Shuta Furzer, Oliver J. Cevik, Volkan Kim, Dae Sung Ishaque, Naveed Goritschnig, Sandra Staskawicz, Brian J. Shirasu, Ken Jones, Jonathan D. G. Nat Commun Article Pathogen co-evolution with plants involves selection for evasion of host surveillance systems. The oomycete Hyaloperonospora arabidopsidis (Hpa) causes downy mildew on Arabidopsis, and race-specific interactions between Arabidopsis accessions and Hpa isolates fit the gene-for-gene model in which host resistance or susceptibility are determined by matching pairs of plant Resistance (R) genes and pathogen Avirulence (AVR) genes. Arabidopsis Col-0 carries R gene RPP4 that confers resistance to Hpa isolates Emoy2 and Emwa1, but its cognate recognized effector(s) were unknown. We report here the identification of the Emoy2 AVR effector gene recognized by RPP4 and show resistance-breaking isolates of Hpa on RPP4-containing Arabidopsis carry the alleles that either are not expressed, or show cytoplasmic instead of nuclear subcellular localization. Nature Publishing Group UK 2018-12-05 /pmc/articles/PMC6281644/ /pubmed/30518923 http://dx.doi.org/10.1038/s41467-018-07469-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Asai, Shuta
Furzer, Oliver J.
Cevik, Volkan
Kim, Dae Sung
Ishaque, Naveed
Goritschnig, Sandra
Staskawicz, Brian J.
Shirasu, Ken
Jones, Jonathan D. G.
A downy mildew effector evades recognition by polymorphism of expression and subcellular localization
title A downy mildew effector evades recognition by polymorphism of expression and subcellular localization
title_full A downy mildew effector evades recognition by polymorphism of expression and subcellular localization
title_fullStr A downy mildew effector evades recognition by polymorphism of expression and subcellular localization
title_full_unstemmed A downy mildew effector evades recognition by polymorphism of expression and subcellular localization
title_short A downy mildew effector evades recognition by polymorphism of expression and subcellular localization
title_sort downy mildew effector evades recognition by polymorphism of expression and subcellular localization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281644/
https://www.ncbi.nlm.nih.gov/pubmed/30518923
http://dx.doi.org/10.1038/s41467-018-07469-3
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