Intra-amniotic Sildenafil Treatment Modulates Vascular Smooth Muscle Cell Phenotype in the Nitrofen Model of Congenital Diaphragmatic Hernia

The etiology of pulmonary vascular abnormalities in CDH is incompletely understood. Studies have demonstrated improvement in pulmonary vasculature with prenatal therapy in animal models. We hypothesize that prenatal sildenafil may attenuate defective pulmonary vascular development via modulation of...

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Detalles Bibliográficos
Autores principales: Okolo, Frances C., Zhang, Guangfeng, Rhodes, Julie, Potoka, Douglas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281652/
https://www.ncbi.nlm.nih.gov/pubmed/30518769
http://dx.doi.org/10.1038/s41598-018-34948-w

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