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Parallel and functionally segregated processing of task phase and conscious content in the prefrontal cortex

The role of lateral prefrontal cortex (LPFC) in mediating conscious perception has been recently questioned due to potential confounds resulting from the parallel operation of task related processes. We have previously demonstrated encoding of contents of visual consciousness in LPFC neurons during...

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Autores principales: Kapoor, Vishal, Besserve, Michel, Logothetis, Nikos K., Panagiotaropoulos, Theofanis I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281663/
https://www.ncbi.nlm.nih.gov/pubmed/30534607
http://dx.doi.org/10.1038/s42003-018-0225-1
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author Kapoor, Vishal
Besserve, Michel
Logothetis, Nikos K.
Panagiotaropoulos, Theofanis I.
author_facet Kapoor, Vishal
Besserve, Michel
Logothetis, Nikos K.
Panagiotaropoulos, Theofanis I.
author_sort Kapoor, Vishal
collection PubMed
description The role of lateral prefrontal cortex (LPFC) in mediating conscious perception has been recently questioned due to potential confounds resulting from the parallel operation of task related processes. We have previously demonstrated encoding of contents of visual consciousness in LPFC neurons during a no-report task involving perceptual suppression. Here, we report a separate LPFC population that exhibits task-phase related activity during the same task. The activity profile of these neurons could be captured as canonical response patterns (CRPs), with their peak amplitudes sequentially distributed across different task phases. Perceptually suppressed visual input had a negligible impact on sequential firing and functional connectivity structure. Importantly, task-phase related neurons were functionally segregated from the neuronal population, which encoded conscious perception. These results suggest that neurons exhibiting task-phase related activity operate in the LPFC concurrently with, but segregated from neurons representing conscious content during a no-report task involving perceptual suppression.
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spelling pubmed-62816632018-12-10 Parallel and functionally segregated processing of task phase and conscious content in the prefrontal cortex Kapoor, Vishal Besserve, Michel Logothetis, Nikos K. Panagiotaropoulos, Theofanis I. Commun Biol Article The role of lateral prefrontal cortex (LPFC) in mediating conscious perception has been recently questioned due to potential confounds resulting from the parallel operation of task related processes. We have previously demonstrated encoding of contents of visual consciousness in LPFC neurons during a no-report task involving perceptual suppression. Here, we report a separate LPFC population that exhibits task-phase related activity during the same task. The activity profile of these neurons could be captured as canonical response patterns (CRPs), with their peak amplitudes sequentially distributed across different task phases. Perceptually suppressed visual input had a negligible impact on sequential firing and functional connectivity structure. Importantly, task-phase related neurons were functionally segregated from the neuronal population, which encoded conscious perception. These results suggest that neurons exhibiting task-phase related activity operate in the LPFC concurrently with, but segregated from neurons representing conscious content during a no-report task involving perceptual suppression. Nature Publishing Group UK 2018-12-05 /pmc/articles/PMC6281663/ /pubmed/30534607 http://dx.doi.org/10.1038/s42003-018-0225-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kapoor, Vishal
Besserve, Michel
Logothetis, Nikos K.
Panagiotaropoulos, Theofanis I.
Parallel and functionally segregated processing of task phase and conscious content in the prefrontal cortex
title Parallel and functionally segregated processing of task phase and conscious content in the prefrontal cortex
title_full Parallel and functionally segregated processing of task phase and conscious content in the prefrontal cortex
title_fullStr Parallel and functionally segregated processing of task phase and conscious content in the prefrontal cortex
title_full_unstemmed Parallel and functionally segregated processing of task phase and conscious content in the prefrontal cortex
title_short Parallel and functionally segregated processing of task phase and conscious content in the prefrontal cortex
title_sort parallel and functionally segregated processing of task phase and conscious content in the prefrontal cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281663/
https://www.ncbi.nlm.nih.gov/pubmed/30534607
http://dx.doi.org/10.1038/s42003-018-0225-1
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