Cargando…
Fecal Short Chain Fatty Acids and Dietary Intake in Italian Women With Restrictive Anorexia Nervosa: A Pilot Study
Nutritional disorders such as Anorexia Nervosa (AN) can shape the composition of gut microbiota and its metabolites such as short chain fatty acid (SCFA). This study aims to compare fecal SCFA along with dietary intake of women with restrictive AN (r-AN = 10) and those of sex-matched lean controls (...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281687/ https://www.ncbi.nlm.nih.gov/pubmed/30555830 http://dx.doi.org/10.3389/fnut.2018.00119 |
_version_ | 1783378865341595648 |
---|---|
author | Speranza, Enza Cioffi, Iolanda Santarpia, Lidia Del Piano, Concetta De Caprio, Carmela Naccarato, Marianna Marra, Maurizio De Filippo, Emilia Contaldo, Franco Pasanisi, Fabrizio |
author_facet | Speranza, Enza Cioffi, Iolanda Santarpia, Lidia Del Piano, Concetta De Caprio, Carmela Naccarato, Marianna Marra, Maurizio De Filippo, Emilia Contaldo, Franco Pasanisi, Fabrizio |
author_sort | Speranza, Enza |
collection | PubMed |
description | Nutritional disorders such as Anorexia Nervosa (AN) can shape the composition of gut microbiota and its metabolites such as short chain fatty acid (SCFA). This study aims to compare fecal SCFA along with dietary intake of women with restrictive AN (r-AN = 10) and those of sex-matched lean controls (C = 8). The main fecal short chain fatty acids (SCFA) were assessed by gas chromatography equipped with a flame ionization detector. All participants completed 7-day food record and underwent indirect calorimetry for measuring resting energy expenditure (REE). Butyrate and propionate fecal concentrations were significantly reduced in r-AN patients compared to controls. The intake of carbohydrate and fat was significantly lower in r-AN patients than controls as well as energy intake and REE; whereas the amount of protein and fiber did not differ between groups. These preliminary results showed that r-AN patients had a reduced excretion of fecal SCFA, likely as a mechanism to compensate for the lower energy and carbohydrate intake observed between groups. Therefore, further studies need to be performed in patients with AN to explore the link between nutritional disorders, gut microbiota and its metabolites. |
format | Online Article Text |
id | pubmed-6281687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62816872018-12-14 Fecal Short Chain Fatty Acids and Dietary Intake in Italian Women With Restrictive Anorexia Nervosa: A Pilot Study Speranza, Enza Cioffi, Iolanda Santarpia, Lidia Del Piano, Concetta De Caprio, Carmela Naccarato, Marianna Marra, Maurizio De Filippo, Emilia Contaldo, Franco Pasanisi, Fabrizio Front Nutr Nutrition Nutritional disorders such as Anorexia Nervosa (AN) can shape the composition of gut microbiota and its metabolites such as short chain fatty acid (SCFA). This study aims to compare fecal SCFA along with dietary intake of women with restrictive AN (r-AN = 10) and those of sex-matched lean controls (C = 8). The main fecal short chain fatty acids (SCFA) were assessed by gas chromatography equipped with a flame ionization detector. All participants completed 7-day food record and underwent indirect calorimetry for measuring resting energy expenditure (REE). Butyrate and propionate fecal concentrations were significantly reduced in r-AN patients compared to controls. The intake of carbohydrate and fat was significantly lower in r-AN patients than controls as well as energy intake and REE; whereas the amount of protein and fiber did not differ between groups. These preliminary results showed that r-AN patients had a reduced excretion of fecal SCFA, likely as a mechanism to compensate for the lower energy and carbohydrate intake observed between groups. Therefore, further studies need to be performed in patients with AN to explore the link between nutritional disorders, gut microbiota and its metabolites. Frontiers Media S.A. 2018-11-29 /pmc/articles/PMC6281687/ /pubmed/30555830 http://dx.doi.org/10.3389/fnut.2018.00119 Text en Copyright © Speranza, Cioffi, Santarpia, Del Piano, De Caprio, Naccarato, Marra, De Filippo, Contaldo and Pasanisi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Speranza, Enza Cioffi, Iolanda Santarpia, Lidia Del Piano, Concetta De Caprio, Carmela Naccarato, Marianna Marra, Maurizio De Filippo, Emilia Contaldo, Franco Pasanisi, Fabrizio Fecal Short Chain Fatty Acids and Dietary Intake in Italian Women With Restrictive Anorexia Nervosa: A Pilot Study |
title | Fecal Short Chain Fatty Acids and Dietary Intake in Italian Women With Restrictive Anorexia Nervosa: A Pilot Study |
title_full | Fecal Short Chain Fatty Acids and Dietary Intake in Italian Women With Restrictive Anorexia Nervosa: A Pilot Study |
title_fullStr | Fecal Short Chain Fatty Acids and Dietary Intake in Italian Women With Restrictive Anorexia Nervosa: A Pilot Study |
title_full_unstemmed | Fecal Short Chain Fatty Acids and Dietary Intake in Italian Women With Restrictive Anorexia Nervosa: A Pilot Study |
title_short | Fecal Short Chain Fatty Acids and Dietary Intake in Italian Women With Restrictive Anorexia Nervosa: A Pilot Study |
title_sort | fecal short chain fatty acids and dietary intake in italian women with restrictive anorexia nervosa: a pilot study |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281687/ https://www.ncbi.nlm.nih.gov/pubmed/30555830 http://dx.doi.org/10.3389/fnut.2018.00119 |
work_keys_str_mv | AT speranzaenza fecalshortchainfattyacidsanddietaryintakeinitalianwomenwithrestrictiveanorexianervosaapilotstudy AT cioffiiolanda fecalshortchainfattyacidsanddietaryintakeinitalianwomenwithrestrictiveanorexianervosaapilotstudy AT santarpialidia fecalshortchainfattyacidsanddietaryintakeinitalianwomenwithrestrictiveanorexianervosaapilotstudy AT delpianoconcetta fecalshortchainfattyacidsanddietaryintakeinitalianwomenwithrestrictiveanorexianervosaapilotstudy AT decapriocarmela fecalshortchainfattyacidsanddietaryintakeinitalianwomenwithrestrictiveanorexianervosaapilotstudy AT naccaratomarianna fecalshortchainfattyacidsanddietaryintakeinitalianwomenwithrestrictiveanorexianervosaapilotstudy AT marramaurizio fecalshortchainfattyacidsanddietaryintakeinitalianwomenwithrestrictiveanorexianervosaapilotstudy AT defilippoemilia fecalshortchainfattyacidsanddietaryintakeinitalianwomenwithrestrictiveanorexianervosaapilotstudy AT contaldofranco fecalshortchainfattyacidsanddietaryintakeinitalianwomenwithrestrictiveanorexianervosaapilotstudy AT pasanisifabrizio fecalshortchainfattyacidsanddietaryintakeinitalianwomenwithrestrictiveanorexianervosaapilotstudy |