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Intrinsic Expression of Immune Checkpoint Molecule TIGIT Could Help Tumor Growth in vivo by Suppressing the Function of NK and CD8(+) T Cells

TIGIT, an immune checkpoint molecule widely expressed on NK cells, activated T cells and Tregs, has been involved in delivering inhibitory signals through the interaction with PVR. The blockade of TIGIT/PVR interaction is a promising approach in cancer immunotherapy. Here, we unexpectedly discovered...

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Detalles Bibliográficos
Autores principales:	Zhou, Xiu-Man, Li, Wan-Qiong, Wu, Ya-Hong, Han, Lu, Cao, Xin-Guang, Yang, Xuan-Ming, Wang, Hong-Fei, Zhao, Wen-Shan, Zhai, Wen-Jie, Qi, Yuan-Ming, Gao, Yan-Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281988/ https://www.ncbi.nlm.nih.gov/pubmed/30555485 http://dx.doi.org/10.3389/fimmu.2018.02821

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