Cargando…

Sequential Prodrug Strategy To Target and Eliminate ACPA-Selective Autoreactive B Cells

[Image: see text] Autoreactive B cells are thought to play a pivotal role in many autoimmune diseases. Rheumatoid arthritis (RA) is an autoimmune disease affecting ∼1% of the Western population and is hallmarked by the presence of anticitrullinated proteins antibodies (ACPA) produced by autoreactive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lelieveldt, Lianne P. W. M., Kristyanto, Hendy, Pruijn, Ger J. M., Scherer, Hans Ulrich, Toes, René E. M., Bonger, Kimberly M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282105/ https://www.ncbi.nlm.nih.gov/pubmed/30289723 http://dx.doi.org/10.1021/acs.molpharmaceut.8b00741

Ejemplares similares

Multifunctional, Multivalent PIC Polymer Scaffolds for Targeting Antigen-Specific, Autoreactive B Cells
por: Kristyanto, Hendy, et al.
Publicado: (2022)

MRI-detected osteitis is not associated with the presence or level of ACPA alone, but with the combined presence of ACPA and RF
por: Boeters, Debbie M., et al.
Publicado: (2016)

ACPA fine-specificity profiles in early rheumatoid arthritis patients do not correlate with clinical features at baseline or with disease progression
por: van Beers, Joyce JBC, et al.
Publicado: (2013)

The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA
por: Suwannalai, Parawee, et al.
Publicado: (2011)

The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical
por: Boeters, Debbie M., et al.
Publicado: (2017)

Autoantikörper und die autoreaktive Immunantwort: ACPA sind mehr als nur ACPA
por: Scherer, H. U.
Publicado: (2020)

Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation
por: Kissel, Theresa, et al.
Publicado: (2022)

Autoreactive B cells in rheumatoid arthritis include mainly activated CXCR3(+) memory B cells and plasmablasts
por: Reijm, Sanne, et al.
Publicado: (2023)

Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA(+) rheumatoid arthritis
por: Sonigra, Amee, et al.
Publicado: (2022)

An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting
por: van Heemst, Jurgen, et al.
Publicado: (2015)

N-Glycosylation Site Analysis of Citrullinated Antigen-Specific B-Cell Receptors Indicates Alternative Selection Pathways During Autoreactive B-Cell Development
por: Vergroesen, Rochelle D., et al.
Publicado: (2019)

Response to the ACPA's critique.
por: Repetto, R, et al.
Publicado: (1998)

Phenylglyoxal-Based Visualization of Citrullinated Proteins on Western Blots
por: Hensen, Sanne M. M., et al.
Publicado: (2015)

Inflammation functions as a key mediator in the link between ACPA and erosion development: an association study in Clinically Suspect Arthralgia
por: ten Brinck, R. M., et al.
Publicado: (2018)

CCR6(+) Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis
por: Paulissen, Sandra M. J., et al.
Publicado: (2015)

Decreased serum cell-free DNA levels in rheumatoid arthritis
por: Dunaeva, Marina, et al.
Publicado: (2015)

Proteogenomic analysis of the autoreactive B cell repertoire in blood and tissues of patients with Sjögren’s syndrome
por: Broeren, Mathijs G A, et al.
Publicado: (2022)

Anti-citrullinated fibronectin antibodies in rheumatoid arthritis are associated with human leukocyte antigen-DRB1 shared epitope alleles
por: van Beers, Joyce JBC, et al.
Publicado: (2012)

ACPA-negative and ACPA-positive RA patients achieving disease resolution demonstrate distinct patterns of MRI-detected joint-inflammation
por: Verstappen, Marloes, et al.
Publicado: (2022)

Patients with ACPA-positive and ACPA-negative rheumatoid arthritis show different serological autoantibody repertoires and autoantibody associations with disease activity
por: Cunningham, Kevin Y., et al.
Publicado: (2023)

Genetic correlates of autoreactivity and autoreactive potential in human Ig heavy chains
por: Volpe, Joseph M, et al.
Publicado: (2009)

ACPA-positive and ACPA-negative rheumatoid arthritis differ in their requirements for combination DMARDs and corticosteroids: secondary analysis of a randomized controlled trial
por: Seegobin, Seth D, et al.
Publicado: (2014)

Immunoprofiling of early, untreated rheumatoid arthritis using mass cytometry reveals an activated basophil subset inversely linked to ACPA status
por: Koppejan, H., et al.
Publicado: (2021)

A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis
por: Padyukov, Leonid, et al.
Publicado: (2010)

Citrullination and Carbamylation in the Pathophysiology of Rheumatoid Arthritis
por: Pruijn, Ger J. M.
Publicado: (2015)

ACPAs Are Much More Than Diagnostic Autoantibodies
por: Watad, Abdulla, et al.
Publicado: (2016)

The Infectious Basis of ACPA-Positive Rheumatoid Arthritis
por: Sakkas, Lazaros I., et al.
Publicado: (2017)

Bioorthogonal Reactions in Activity-Based Protein Profiling
por: Verhelst, Steven H. L., et al.
Publicado: (2020)

A Comparison of Immunoglobulin Variable Region N-Linked Glycosylation in Healthy Donors, Autoimmune Disease and Lymphoma
por: Vletter, Esther M., et al.
Publicado: (2020)

Induction of autoreactive B cells allows priming of autoreactive T cells
Publicado: (1991)

High-specificity bioinformatics framework for epigenomic profiling of discordant twins reveals specific and shared markers for ACPA and ACPA-positive rheumatoid arthritis
por: Gomez-Cabrero, David, et al.
Publicado: (2016)

The P. gingivalis Autocitrullinome Is Not a Target for ACPA in Early Rheumatoid Arthritis
por: Muñoz-Atienza, E., et al.
Publicado: (2020)

Induction of long-term B-cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity
por: Teng, YK Onno, et al.
Publicado: (2012)

ACPA: automated cluster plot analysis of genotype data
por: Schillert, Arne, et al.
Publicado: (2009)

Ways forward to identify new ACPA targets in RA
por: Ytterberg, A Jimmy, et al.
Publicado: (2012)

Measuring ACPA in the general population or primary care: is it useful?
por: Finckh, Axel, et al.
Publicado: (2020)

The RNA interference pathway: a new target for autoimmunity
por: Pruijn, Ger JM
Publicado: (2006)

The monobloc hydrogel breast implant, experiences and ideas
por: Kappel, Rita M., et al.
Publicado: (2011)

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25(+) Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses
por: Sutmuller, Roger P.M., et al.
Publicado: (2001)

Thousands of CpGs Show DNA Methylation Differences in ACPA-Positive Individuals
por: Zeng, Yixiao, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qn2t8qpqhma6k23slg7u831hgg